Endocrine Abstracts

Introduction: Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and HMG-CoA hepatic reductase, indirectly regulating the body’s lipid metabolism. This mechanism is already known, however the principles of regulating lipid metabolism through thyroid metabolism constitute an important and a desirable element of scientific research in thyreology. Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and HMG-CoA hepatic reductase, indirectly regulating the body’s lipid metabolism. This mechanism is already known, however the principles of regulating lipid metabolism through thyroThe aim of the study was to assess the relationship between TSH, fT3 and fT4 concentrations and lipid parameters, as well as to identify differences in individual thyroid gland dysfunctions.m constitute an important and a desirable element of scientific research in thyreology.

Material and Methods: The medical records of 1470 patients were analyzed (gender, TSH, fT3, fT4, total cholesterol, HDL-C, LDL-C, triglycerides as well as the percentage of HDL-C and LDL-C relative to total cholesterol level). Patients receiving statin therapy were excluded from the study. The collected data was statistically analyzed using the STATISTICA 13.3 statistical package

Results: TSH correlated with total cholesterol (r = 0.10), LDL-C (r = 0.08), and triglycerides (r = 0.10), but not with HDL-C (P = 0.43). fT3 correlated with total cholesterol (r = 0.13), LDL-C (r = 0.12), HDL-C (r = 0.29), but not with triglycerides (P = 0.16). Correlations regarding TSH were stronger in men, while those related to fT3 and fT4 – in women. Hypothyroidism is associated with a 37% higher risk of triglyceridemia and a 41–62% risk of atherosclerosis compared to the euthyroid population. Full results will be presented during Congress.

Conclusion: The function of the thyroid gland has a significant impact on the lipid metabolism. Correlations between thyroid and lipid parameters show significant diversity based on gender. Full conclusions will be presented during the Congress.