Endocrine Abstracts

Objective: Thyroid hormones are powerful mediators of numerous physiological and metabolic processes, including blood clotting, and thyroid dysfunction can adversely affect various stages in the coagulation cascade. Mean platelet volume (MPV) is used to measure platelet size and may indicate platelet activity. Studies have reported that increased MPV is associated with atherosclerotic lesions and cardiovascular diseases, and conflicting results have been reported for the relationship between thyroid function and MPV. In this study, in the healthy control group and patients with hypothyroidism due to Hashimoto’ thyroiditis, L-thyroxine treatment was given to euthyroid after at least 6 months of treatment. We investigated its effect on platelet aggregation.

Materials and methods: We evaluated 72 patients diagnosed with Hashimato thyroiditis between March 2013 – May 2018 and who were followed for at least 6 months of L-thyroxine treatment.

Results: A total of 72 patients (61 males, 11 females) were included in the study. The control group consisted of 32 healthy individuals (25 female and 7 male). hemoglobin (Hb), mean erythrocyte volume (MCV), MPV and platelet count (PLT) and thyroid function tests were studied in the patient and control groups. There was no significant difference between patient and control groups in terms of mean Hb, MCV, MPV and PLT (P > 0.05). There was no significant difference between the pre- and post-treatment Hb values (P = 0.651) and the mean MCV, MPV and PLT values before and after treatment (P > 0.05).

Conclusion: Hb, MCV, MPV and PLT values of patients with Hashimoto thyroiditis before and after at least 6 months of L-thyroxine treatment were not significantly different. There was no significant difference between the Hb, MCV, MPV and PLT values of the patient group before and after L-thyroxine treatment for at least 6 months.