Endocrine Abstracts

The aim of investigation to examine characteristics of true premature sexual development in children and adolescents over three years.

Material and Methods: We observed 9 children with true premature sexual development (including boy – 1, girls –8), which had treatment in the pediatric department of the Center of Endocrinology in the period from September 2016 to July 2018 years. Patients were measured height, weight, considered a lack of growth, weight, performed a palpation of the thyroid gland and an objective examination of sexual development’ stages by Tanner.

All patients underwent a set of studies, including the clinical (General blood and urine analysis), biochemical, hormonal (LH, FSH, prolactin, estradiol, progesterone, free testosterone). Besides that, we performed pituitary MRI and ultrasound investigation of endocrine organs.

Results: It was established that growth excess occurred in all (100%) patients examined. Hormonal disorders were characterized by an increase in average levels of peripheral sex hormones on the radiographs of the brush in all children, an advance of bone age of 3–4 years was revealed No changes in brain MRI were detected. In 3 patients, isolated telarch was noted. All patients received dipherelin therapy.

Conclusions: In the structure of premature sexual development in children, true is relatively rare. A special screening is required to identify this pathology in children