ECE2020 ePoster Presentations Pituitary and Neuroendocrinology (94 abstracts)
A case report: Pituitary granulomatosis with polyangiitis
Hatice Sebile Dökmetaș 1 , Güneș Çavușoğlu 2 , Fatih Kılıçlı 3 , Meryem Can 3 , Meriç Dökmetaș 2 & Ayșenur Cila 4
1İstanbul Medipol University, Endocrinology and Metabolism, İstanbul, Turkey; 2İstanbul Medipol University, Internal Medicine, İstanbul, Turkey; 3İstanbul Medipol University, Rheumatolgy, İstanbul, Turkey; 4İstanbul Medipol University, Radiology, İstanbul, Turkey
Introduction: Granulomatosis with polyangiitis (GPA) is a systemic vasculitis with necrotizing granulomatous inflammation. Any organ including the pituitary can be involved. Here we report a patient diagnosed with GPA who had nearly complete resolution of pituitary mass after cyclophosphamide and methylprednisolone treatment.
Case
46 year old female patient was admitted to the hospital after being examined by several departments for fever, severe headaches and sinusitis which she had for 2 months. Her inflammatory markers were high and she had cavities seen on her chest radiogram. Her cranial MRI showed a 12 mm-diameter adenoma of cystic and solid components at the right half of the adenohypophysis. Her hormone profile was remarkable except the prolactine [52.84 ng/ml (4.79–23.3) ]. Anti-proteinase 3 antibody is also positive. She didn’t have diabetes insipidus. Pulse methylprednisolone treatment was started, followed by daily methylprednisolone in decreasing doses. Monthly IV cyclophosphamide treatment was also started. 4 months later MRI showed nearly complete resolution of the adenoma and there can only be seen a microcystic focal area at the right upper side of the gland. Her hormones are remarkable including prolactine.
Conclusion: Pituitary masses can rarely be seen in GPA and our patient’s mass resolved with cyclophosphamide and methylprednisolone treatment.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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