ECE2020 ePoster Presentations General Endocrinology (8 abstracts)
Endocrinopathy in patients with glomerulonephritis undergoing renal biopsy – single center observation
Agnieszka Gala-Bladzinska 1,2 , Renata Orłowska-Florek 1,2 , Joanna Sztembis 1 , Katarzyna Rałowska 2 , Anna Opalińska 2 , Julia Nawrocka 2 , Aleksandra Pich 2 & Karolina Wojton 2
1St` Queen Jadwiga Clinical District Hospital No2 in Rzeszów, Department of Internal Medicine, Nephrology and Endocrinology, Rzeszów, Poland; 2Medical College of Rzeszow University, Institute of Medical Sciences, Rzeszów, Poland
Introduction: Endocrine disorders and kidney diseases can coexist. Some of these have a common pathophysiological background. Strategies for treating endocrinopathy or glomerulonephritis (GN) may affect the function of the endocrine system and kidney.
Aim: The study was aimed to assess the correlation of kidney biopsy results performed in people with suspected GN with thyroid function, metabolic syndrome and diabetes occurrence.
Material and Methods: The research consisted of retrospective analysis the data of 233 (79.8% women) patients, the age range of the group was 7–79 (44.5 ± 17.4), hospitalized in our clinic from 2013 to 2019 (75 months) who underwent renal biopsy due to suspected GN.
Results: The most common indications for renal biopsy were: nephrotic syndrome (n = 84; 36%), no nephrotic proteinuria (n = 24; 10.3%), worsening renal function (n = 91; 39.1%), nephritic syndrome (n = 34; 14.6%). Membranous glomerulonephritis (n = 33; 14%), rapidly progressive glomerulonephritis with extra capillary crescents (n = 21; 9%) and focal segmental glomerulosclerosis (n = 21; 9%) was the most common histological diagnosis observed in kidney biopsies. Our analysis proved higher occurrence of thyroid dysfunction: hypothyroidism (n = 29; 12.4%), low FT3 syndrome (n = 30; 13.1%), subclinical hypothyroidism (25; 10.7%). Diabetes coexisted in 32 (13.73%) patients, whereas diabetic nephropathy (DN) was found in renal biopsy only in 6 (2.57%) patients. Many patients had steroid-induced diabetes (14%). There wasn’t higher occurrence of obesity (27.1%) and overweight (24.9%). Arterial hypertension coexisted in 108 (46.3%) patients.
Conclusions: Additional diagnosis for thyroid pathology is worth to be considered in monitoring patients with GN. A small percentage of diabetics had features of DN in kidney biopsy. There was no higher occurrence of obesity and overweight in the population with GN.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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