Endocrine Abstracts

Objective: To analyze correlation between the duration of diabetes mellitus (DM), renal function and androgenic state indicators in patients with DM type 1. 175 males with DM 1 type in the age of 18–55 years (39.75 ± 9.69) with the duration of disease more than 1 year were examined. The control group included 25 almost healthy males in the age 21–41 years (34.60 ± 7.80). The compensation of DM was estimated by the level of glycosylated hemoglobin (HbA1c). Also, the indicators of lipid profile (total cholesterol, triglycerides), glomerular filtration rate (GFR) MDRD, total testosterone, luteinizing hormone/follicle-stimulating hormone (LH/FSH), prolactin, sex hormone-binding globulin, homocysteine. The statistical analysis was conducted with the use of SPSS 17.0. It was defined that there was the decrease of GFR according to the formula MDRD in the terms of the increase of diabetes duration: in the group with GFR < 60 ml/min/1.73 m² the duration of the diabetes was 23.72 years ( ± 8.04), in the group with GFR > 60 ml/min/1.73 m² it was12.15 years ( ± 8.37) (P < 0.05). In the terms of the decrease of GFR the increase of correlation FSH/LH was defined: in the group with GFR < 60 ml/min/1.73 m² the correlation LH/FSH was 1.82 ( ± 0.63), in the group with GFR > 60 ml/min/1.73 m² it was 1.37 ( ± 1.26) (< 0.005); the decrease of the total testosterone: in the group with GFR <60 ml/min/1.73 m² the total testosterone was 9.90 nmol/l ( ± 3.10), in the group with GFR > 60 ml/min/1.73 m² it was 10.61 nmol/l ( ± 8.76) (P < 0.05); the decrease of the homocysteine level was noticed: 11.42 ± 2.70 mcmol/l comparing with the10.32 ± 4.92 mcmol/l in the group with GFR > 60 ml/min/1.73 m² (P = 0.006). We have not revealed any differences in the level of prolactin, sex hormone-binding globulin. The revealed changes are important risk factors for development and progression of vascular complications and require appropriate arrangements.

Keywords: diabetes mellitus type 1, GFR MDRD, androgenic state.