Endocrine Abstracts

Objective to assess homocysteine and B12 basal levels in patients with diabetes mellitus type 1 (DM type 1) depending on anxiety level.

Materials and methods: 163 patients with DM type 1 aged 18–65 years. Diabetes duration is 11.18 [4.28; 22.33] years. The level of anxiety was assessed according to the HADS scale. The homocysteine and vitamin B12 level in serum was determined. Depending on the anxiety level according to the results of the HADS score, patients were divided into 2 subgroups.

Results: The median HC level in serum in patients with anxiety was 13.29 [8.80; 15.90] mmol/l against the median HC level in patients without anxiety – 9.80 [7.94; 11.50] mmol/l and was higher in patients with anxiety (U = 15.12; P = 0.02). The risk of developing anxiety in patients with DM type 1 is associated with a HC level of more than 15.39 mmol/l (OS = 1.21; P = 0.03; 95% CI 1.06–1.37). The median vitamin B12 level in serum in patients with anxiety was 126 pg/ml [28.0; 473.0] against the median vitamin B12 level in serum in patients without anxiety – 312 pg/ml [168.0; 602.0] and was lower in patients with anxiety (U = 14.65; P = 0.04). A negative correlation was established between the level of anxiety by HADS and the level of vitamin B12 in serum (r = –0.19; P < 0.05).

Conclusion: Patients with anxiety have a higher HC level and lower vitamin B12 level than patients without anxiety. With a decrease in vitamin B12 level, an increase in anxiety level by HADS is noted. The risk of developing anxiety in patients with DM type 1 is associated with HC level in serum above 15.39 mmol/l.