Endocrine Abstracts

It has been shown that miR-107 regulates insulin sensitivity, but its status in severe insulin resistance (IR) patients has not been established. In this study, we investigated the expression of microRNA-107 in the sera from patients with clinically severe IR and its relationships with metabolic characteristics.

Methods: The expression of microRNA-107 was detected in the sera of 30 clinically severe IR patients and 24 gender and age-matched control group by quantitative real-time PCR. Patients that daily insulin requirements were > 1 unit/kg/day and HbA1c > 9% – referred as clinically severe IR group, patients that daily insulin requirements were < 0.9 unit/kg/day and HbA1c < 8% – referred as control group. The clinical data were collected and analyzed by statistical software.

Results: In the severe IR group, microRNA-107 level was not higher significantly in the sera (P 0.54).

Conclusions: While microRNA-107 is related with insulin sensitivity, but it is not associated with severe IR.