Endocrine Abstracts

The lifetime risk of pancreatic cancer for the average individual without a family history of pancreatic cancer is approximately 1%. Individuals with a family history of pancreatic cancer are at an increased lifetime risk for developing pancreatic cancer. This risk is likely higher for individuals from a family with FPC. The following cancer risk estimates are generalized and should be interpreted with caution since the actual risk for each individual may be different:We received a case study of two siblings of one family. The older brother was diagnosed with Type 2 Diabetes in 2017 and began insulin therapy at age 72. After one year of treatment with insulin therapy, he had symptoms such as nausea, vomiting, pruritus, weakness, weight loss. While there was no fluctuation of glycemia, with HBA1c = 7%. At this moment all necessary examinations are done and results were magnetic resonance with pancreatic Ca and pulmonary meta. Ca 19–9 = 700.6 .After six months the patient died. In 2018 was present his brother aged 70 with typical signs of Type 2 Diabetes with polydipsia polyuria syndrome and weight loss. Glycemia = 400 mg/dl and HbA1c = 12%. Insulin therapy was started. During one year presented with satisfactory parameters. glycemia and HbA1C. After one year the same signs as brother, nausea, vomiting, headache, generalized pruritus began. Necessary examinations are performed and magnetic resonance results pancreas Ca and Ca19–9 = 1000. Actually the patient is undergoing to radiotherapy and follow–up by the oncologist. In this case, we observed that the disease appeared to be preceded by type 2 diabetes mellitus over the age of 70 and with the same symptoms. Familial pancreatic cancer (FPC) is a term to describe families with an abnormally high rate of pancreatic cancer. Ductal adenocarcinoma of the pancreas, which is the most common type of pancreatic cancer, starts when healthy cells lining the pancreatic ducts change and grow out of control, forming a tumor. The pancreas is a pear–shaped gland found in the abdomen between the stomach and spine. The gland makes enzymes that help the body digest food. It also makes hormones, such as insulin, that help control blood sugar. Families are considered to have FPC if there are at least 2 members of the family with pancreatic cancer who are first–degree relatives, such as a parent, child, or siblings of one another.