Endocrine Abstracts

Background: Different screening programs recommend starting active search for type 2 diabetes (DM2) at age from 35 to 45. This difference comes from variety in structure of population and weight of age as a risk factor, and also has economical background.

The aim of our study: Was to find out the most acceptable cut–off age for DM2 screening in Uzbekistan.

Material and Methods: We analyzed results of type 2 diabetes screening in three regions of the Republic of Uzbekistan among 2521 people aged 35 or older without known carbohydrates metabolism disorders. A1c was tested using method of immune precipitation with anti–human and anti–mouse A1c antibodies (Human), oral glucose tolerance test was performed with 75 g glucose. Diabetes was diagnosed according to IDF recommendations.

Results and discussion: In total, DM2 had 7.9% of analyzed population. When comparing the age groups, DM2 was revealed in 0.92% (1.1% in men and 0.9% in women) at age 35–39, in 3.4% (5.1% in men and 2.9% in women) at age 40–44, and 11.8% (12.1% in men and 11.6% in women) at age 45 or older (10.5% at age 45–59; 16.5% at age 60–74; 11.9% at age 75 or older, which is 11.4%, 16.0%, and 5.6% in men, and 9.9%, 16.7%, and 14.2% in women, respectively). So, significant rise in diabetes was revealed starting from age 45.

Conclusion: Taking into account economic issues, we recommend to start screening for type 2 diabetes in Uzbek population at age 45.