Endocrine Abstracts

Purpose: To study the state of the microvasculature and tissue metabolism (according to the dynamics of the FAD and NADH coenzymes) using laser Doppler fluometry (LDF) and laser fluorescence spectroscopy (LFS) in patients with diabetes mellitus.

Materials and methods: To implement the combined use of LDF and LFS methods, the Laser Diagnostic Device LAZMA ST was used (registration certificate of Roszdravnadzor No. RZN 2017/5844 of June 08, 2017).

The study was conducted on the sole of the big toe, with pre–treatment with an alcohol solution of the surface of the toe.

Criteria for non–inclusion: the presence of violations of the main bloodstream of the vessels of the lower extremities.

Control group: 30 people. Non–inclusion criteria: the presence of cancer, changes in the main blood flow of the lower extremities.

In patients, glycated hemoglobin (HbA1c) was assessed.

Results: 40 patients with diabetes mellitus aged 30 to 70 years were examined using LDF and LPS using functional tests (local thermal and cold tests): 29 women and 11 men. Of these: type 1 diabetes in 3 people, type 2 diabetes in 37 people.

Patients were divided into the following groups:

1) Subcompensated violations:

1 1a – active microcirculation, oxidative metabolism reduced: 14.

2b – microcirculation is inactive, oxidative metabolism is reduced: 4.

3c – active microcirculation, oxidative metabolism reduced markedly: 9.

2) Moderate decompensated disorders of microcirculation and oxidative metabolism: 11.

3) Severe decompensated disorders of microcirculation and oxidative metabolism: 2.

Conclusions (conclusion)

A direct correlation was revealed between the HbA1c indices and the degree of microcirculatory disorders and oxidative metabolism: in group No. 1, HbA1c ranged from 6.5% to 7.2%; in group No. 2 HbA1c in the range of 7.5% – 10.2%; in group No. 3 HbA1c in the range of 10.7% – 12.1%.