Endocrine Abstracts

Obesity is a polyetiological and incompletely studied disease. Recent publications link the special composition of the gut microbiota not only with obesity, but also with its metabolic profile^{1, 2}. To study the characteristics of the gut microbiota in patients with different phenotypes of obesity, 37 patients were examined. In addition to determining the quantitative composition of the gut microbiota by the Real-time PCR method, all participants were determined by lipid and carbohydrate metabolism and 3 groups were identified according to Wildman’s criteria: 1 group (n = 11) - healthy people without obesity and overweight, 2 group( n = 13) - patients with metabolically healthy obesity (MHO), group 3 (n = 13) - patients with metabolically unhealthy obesity (MUHO). The results showed that the differences between the 1st group without obesity and the 2nd group with MHO is in the registration in the feces of Klebsiella spp. and Proteus spp. in amounts exceeding the formal regulatory in patients of group 2. The most significant changes were obtained in group 3 (MUHO): C.difficile was detected, a significant (P = 0.05) decrease in F.prausnitzii and an increase (P = 0.05) in the detection frequency of banal E.coli and a more diverse composition of gut microbiota. The data obtained as a result of our pilot study revealed compositional changes in the gut microbiota among the studied groups, which could potentially be either the cause and / or display different phenotypes of obesity. It is planned to continue further study of the composition of the microbiota of the colon in patients with various phenotypes of obesity, with only a large number of examined in groups to obtain confirmation of the identified changes in the pilot study.

Reference

1. Dao MC, Clément K. Gut microbiota and obesity: Concepts relevant to clinical care. Eur J Intern Med. 2018 Feb; 48: 18–24. doi: 10.1016/j.ejim.2017.10.005.

2. Vallianou N, Stratigou T, Christodoulatos GS, Dalamaga M. Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity–Associated Metabolic Disorders: Current Evidence and Perspectives. Curr Obes Rep. 2019 Sep; 8(3) 317–332. doi: 10.1007/s13679–019–00352–2.