Endocrine Abstracts

Introduction: T2DM prevalence in Belarus is 3.489.5 per 100 thousand people, annual growth rate is 5–6%. STEPS study: in 2016–2017 the following risk factors prevailed: overweight and obesity (61.2%), dyslipidemia (36%), hypertension (50%); inactive lifestyle (78.2%). The study aim was to assess risk factors for metabolic disorders in a young healthy population. Objective. 253 people were examined: 22.1% of men and 77.9% of women under 40. Methods: We performed anthropometric measurements, determined glycemia and total cholesterol levels; 10–year risk of developing T2DM was assessed according to the FINDRISK scale, and 10–year fatal risk of events associated with atherosclerosis – according to the SCORE scale.

Results: Median age was 30 (24; 34), BMI – 23.7 (20.4; 26.6), systolic blood pressure – (115 ± 14), diastolic blood pressure – (77 ± 11) mmHg, point on the FINDRISK scale – 5 (2; 8), a very high 10–year risk of T2DM was not obtained, high – in 5.6% of women, interim – in 22.2% of women and 16.7% of men, moderate – in 5.6% of women and 16.7% of men, low – in 66.6% of women and men. Statistically significant association of risk factors for T2DM and atherosclerosis depending on gender, blood pressure, or total cholesterol was not obtained. We noted a significant correlation of the risk of T2DM with BMI (rs = 0.82; P < 0.05), with total cholesterol (rs = 0.77; P < 0.05) and glycemia (rs = 0.42; rs.05). Direct significant correlation was also obtained for the visceral adiposity index: 0.77 × TCHOL (CM) - 0.46 × BMI (kg/m²) – 5.82 (model P = 0.000002) with a risk level according to FINDRISK scale (rs = 0.71; P<0.05) and glycemia (rs = 0.45; P < 0.05).

Conclusion: In people under 40 with no risk of fatal complications associated with atherosclerosis, there is a number of factors indicating a risk of T2DM, which should be taken into account at forming different risk groups for prevention.