Endocrine Abstracts

Background: Studies show relationship between serum uric acid (SUA) and such diseases as type 2 diabetes (T2DM), hypertension (HT) and atherosclerotic cardiovascular disease (ASCVD). There is relationship both in hyperuricemia (HU), and high–normal values of SUA. Significance of this association is unknown; there are controversial data concerning HU role in patients with T2DM/CVD.

The aim of the study was to assess SUA in T2DM patients with ASCVD.

Method: Participants were 82 hypertensive T2DM patients, treated for HT or CVD; 52 patients had established ASCVD: CAD (previous myocardial infarction/MI, or/and PCI, CABG ), peripheral artery disease/PAD (ankle–brachial index < 0.9), or/and stroke (by MRI-data). At entry 83% were receiving hypotensive drugs (one or more), half of them weren’t treated adequately. Statins were used in 61 patient. Participants were divided into 2 groups (Gr). G.r.1, 52 patients with ASCVD (mean age 60.1 ± 7.5yrs, 39men/13women: 35 with CAD (23 – after MI; 21 – after PCI; 11 – after GABG); 14 – with PAD (four PAD + CAD); 13 – after stroke (3 PAD + CAD). Gr.2: 30 hypertensive patients without ASCVD (mean age 58.8 ± 8.4yrs, 22men/8women). Diabetes duration (DD), SUA, HbA1c, LDL-cholesterol, triglyceride, systolic/diastolic blood pressure (SBP/DBP), body mass index (BMI) were assessed.

Results: SUA was higher, (5.77 ± 0.61 vs 4.02 ± 0.53, P = 0.033); DD longer (11.95 ± 2.3 vs 6.1 ± 1.8 yrs, P = 0.04); SBP higher (152 ± 5.3 vs 137 ± 4.9 mmHg, P = 0.04), and BMI was higher ( 33.9 ± 2.3 vs 27.4 ± 2.1, P = 0.04) in Gr.1 compared to Gr.2. There was not statistically significant difference in DBP (84.5 ± 6.3 vs 81.3 ± 5.1 mmHg, P = 0.69 ), HbA1c (8.3 ± 1.02 vs 8.6 ± 0.9%, P = 0.8 ); LDL–cholesterol ( 2.57 ± 1.09 vs 2.31 ± 1.1 mmol/dl, P = 0.867) and triglycerides (2.04 ± 0.8 vs 1.91 ± 0.7 mmol/l, P = 0.902) between two groups. BMI was higher in Gr.1 compared to Gr.2.( 33.9 ± 2.3 vs 27.4 ± 2.1, P = 0.04).

Conclusion: T2DM + ASCVD patients have higher SUA compared to Gr.2, ASCVD patients were more hypertensive, obese and had longer DD . Further studies are necessary to assess significance of SUA as an independent risk-factor for ASCVD development in T2DM.