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Endocrine Abstracts (2020) 70 AEP969 | DOI: 10.1530/endoabs.70.AEP969

1Hospital Reina Sofía, Endocrinology and Nutrition, Córdoba, Spain; 2Hospital Reina Sofía, Radiology, Córdoba, Spain


Introduction: Thyroid ultrasound is the main technique to study this gland’s pathology. ACR TI-RADS system evaluates the malignancy risk in thyroid nodules according to their sonographic features and stablishes the size in which to perform fine needle aspiration (FNA) for its cytological study. Nodules diagnosed as Bethesda category 4 (B4) means are follicular neoplasms or suspicious for follicular neoplasms.

Aim: Determine the pathology diagnosis of B4 nodules and study associations among malignancy and ACR-TIRADS sonographic features.

Material and Methods: Retrospective study of thyroid nodules classified as B4 in FNA in our hospital between 2012 and 2018. Statistical analysis: SPSS v.22.0 (Student’s t-test to compare means and Squared Chi/Fisher to proportions).

Results: 162 nodules classified as B4 in FNA. Mean age: 54.07 ± 14.62 years. 75.3% Women. 2.6% nodules stratified as ACR TI-RADS 2 with mean longest diameter (MLD) of 35.25 cm. 23.9% ACR TI-RADS 3 with MLD of 31.94 mm, 66.5% ACR TI-RADS 4 with MLD of 30.19 mm and 7.1% ACR TI-RADS 5 with a MLD of 29.09 mm.

CompositionEchogenicityShapeMarginEchogenic Foci
Feature%Feature%Feature%Feature%Feature%
Cystic or almost completely cystic0Hyperechoic or isoechoic24.5Wider than tall94.2Smooth93.5None or large comet-tail artifacts87.1
Spongiform0Hypoechoic71.0Taller than wide5.8Lobulated or irregular6.5Macro-calcifications5.8
Mixed3.9Very-hipoechoic4.5Extra-thyroidal extension0%Peripheralcalcifications1.3
Solid or almost completely solid96.1Punctate echogenic foci5.8

29 (17.8%) nodules met standard malignancy criteria: 15 papillary thyroid carcinomas, 12 follicular thyroid carcinomas and 2 medullary carcinomas. If ACR TI-RADS had been strictly followed, 25.2% of FNA could have been avoided. Among nodules without FNA indication, 3 were malignant (2 papillary and 1 follicular carcinoma). Of those with FNA indication 24.5% were malignant. In our cohort, ACR TI-RADS system was of 88.8% (CI 95% 1.08–0.77) and specificity of 30.2% (CI 95% 0.38–0.21). Positive predictive value was 24% and negative predictive valuewas 91%.

Conclusions: FNA performed could have been reduced in our cohort if the decision had been taken upon the strict application of ACR TI-RADS system. Given the low rate of false negative nodules, ACR-TIRADS constitutes a good screening method to determine which nodules should undergo FNA.

Volume 70

22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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