Endocrine Abstracts

Aim: Study the correlation between leptin and renal malfunction in patients with primary hypothyroidism (PH).

Methods: 161 patients suffering from PH took part in the investigation. Criteria of choice were as follows: patients’ age from 36 to 60 and presence of PH. Presence of any acute or chronic renal disease or ischemic heart disease was the criteria of exclusion. The diagnosis was made on the basis of complaints, family history, typical clinical sign of manifested hypothyroidism and was confirmed by the results of hormonal analyses.

Results: Among 152 examined patients, barrier malfunction was found in 52.6% of patients, out of which 46.6% had albuminuria, and 6% had proteinuria. Early stage of nephropathy was found in 24% of patients. Patients diagnosed with abnormal renal function were divided into four groups taking into account their body weight index (BWI), since this factor has a significant effect on changes in mentioned above parameters. Patients with PH on the basis of Hashimoto thyroiditis with BWI < 24.9 kg/m² and BWI > 25 kg/m² were included to IA and IB groups correspondingly. Group II A and II B encompassed patients with postoperative hypothyroidism (PH) with BWI < 24.9 kg/m² and BWI > 25 kg/m² correspondingly. At the same time, calculating RGF by MDRD formula considering sex and age, its value was found to be quite low (77.99 ± 2.18) and essentially differed from the data received in the control group. Patients with PH and excessive body weight showed much lower RGF in comparison to control group (P < 0.001). Evaluating the leptin level it was noted that the bigger body weight patients with PH had the higher concentration of leptin in blood serum was revealed. Thus, patients with hypothyroidism and Hashimoto thyroiditis had leptin level two times higher in the group with BWI > 24.9 kg/m² than in the group with BWI < 24.9 kg/m², and in the group of patients with PH this level is three times higher. Hyperleptinemia is closely related to anthropometric indices and functional parameters of kidneys. The most distinct reverse contact was traced between leptin and RGF and direct contact–among waist circumference, BWI and albumin secretion.

Conclusion: Patients with manifested hypothyroidism have revealed renal malfunction, predisposed by such risk factor as hyperleptinemia, overweight and abdominal obesity.