Endocrine Abstracts

Introduction: Hyperthyroidism is characterised by an increased hormone synthesis, with non-specific and pleomorphic clinical features. Management strategy, depends entirely on the etiological status ; as part of an holistic vision. The purpose of this study is to shed light on epidemiological, clinical, etiological and therapeutic aspects of hyperthyroidism in Endocrinology & Diabetology department of Oujda’s Mohammed VI university hospital.

Material and Methods: Prospective data analysis of patients with hyperthyroidism followed up in Endocrinology & Diabetology department of Oujda’s Mohammed VI university hospital.

Résults: 186 patients were enrolled in the study. The overall mean age was 43.9 years old with a female predominance (83.9%). 18.7% of the patients had a family history of dysthyroidism. Clinicalhyperthyroidism features have been considered as the presenting complaint in 67% of all the cases, and thyroid orbitopathy have been noticed in 15.6% of patients. The mean serum concentrations of Ultrasensitive TSH and free T4 were around 0.09 mUI/l and 50.4 pmol/l respectively. Clearly elevated Thyrotropin Receptor antibodies (TRAb) and Anti-Thyroid Peroxydase antibodies (anti-TPO) were noticed in 52.4% and 45.1% of cases respectively. Grave’s disease and toxic nodular goiter were identified in 61.4% of the patients, as the 2 major etiologies of thyrotoxicosis in our study. 97.8% of the patients underwent antithyroid drug therapy, and b-adrenergic blocker was added basically in 42.5% of the cases. Neutropenia was observed only in 3.9% of the patients. A total thyroidectomy was proceeded in 36.4% of cases and 31.1% preferred Radio Iodine (I-131) therapy.

Conclusion: Hyperthyroidism is considered as a frequent endocrinopathy which can be easily diagnosed. However,chosing an eminent therapeutic pathway remains a matter of debate and a challenge for every clinician.