ECE2020 Audio ePoster Presentations Thyroid (144 abstracts)
Predictive value of free triiodothyronine within normal range on cardiovascular events in a Chinese cohort with coronary artery disease: Direct effect and mediation effect by TG
Jun Wen 1 , Fei Su 2 , Xuan Li 2,3 , Na-Qiong Wu 1 , Ying Gao 1 , Geng Liu 1 , Qian Dong 1 , Yi-Da Tang 1 , Jian-Jun Li 1 & Yuan-Lin Guo 1
1Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China, Endocrinology and cardiovascular metabolism Center, Beijing, China; 2Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Clinical Biobank, Beijing, China; 3The Chinese University of Hong Kong, Shenzhen, Shenzhen, Guangdong, China
Background and aims: Coronary artery disease (CAD) plays an important role in global mortality worldwide. Risk assessment for patients with CAD through free triiodothyronine (FT3) remains unclear. Therefore, we aimed to investigate the impact of FT3 on the prognosis of patients with CAD.
Methods: A total of 0 patients with CAD and available FT3 data, and without overt thyroid disease were enrolled in this study and grouped by tertiles. The primary outcome was termed cardiovascular events (CVEs), including cardiovascular mortality, non-fatal myocardial infarction and stroke. Association of FT3 with 3-year CVEs was assessed through multivariate Cox regression analysis and mediation analysis.
Results: During median follow-up 2 years, 162 (2%) CVEs occurred. FT3 levels were negatively associated 5824 with incident CVEs (hazard ratio, 0.59; 95%confidence interval, 0.36–0.96). Compared with the low FT3 tertile, the high tertile had significantly lower risk of CVEs (HR, 0.59; 95% CI, 0.38–0.92). Meanwhile, triglyceride mediated the association between FT3 and risk of CVEs (HR, 0.98; 95% CI, 0.969–0.996; P < 0.05). Moreover, FT3 significantly improved discrimination and reclassification of the Framingham secondary event model and the ABC-CHD model in our cohort. Results remained similar or became stronger in FT3 levels within the normal range.
Conclusion: Lower FT3 levels were associated with an increased risk of CVEs, partly mediated through higher triglyceride, suggesting that FT3 is a potential biomarker for a better risk stratification and perfect management in patients with CAD. Further studies are needed to confirm our findings.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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