ECE2020 Audio ePoster Presentations Thyroid (144 abstracts)
Follicular fluid progesterone in thyroid autoantibodies positive women and assisted reproductive technology outcome
Sanja Medenica 1 , Eliana Garalejic 2,3 , Biljana Arsic 2 , Biljana Medjo 3,4 , Dragana Bojovic Jovic 2 , Dzihan Abazovic 5 , Rade Vukovic 6 , Snezana Vujosevic 1,7 & Milos Zarkovic 3,8
1Clinical Center of Montenegro, Department of Endocrinology, Internal Medicine Clinic, Podgorica, Montenegro; 2Clinic for Gynecology and Obstetrics ‘Narodni front’, In Vitro Fertilisation Department, Belgrade, Serbia; 3School of Medicine, University of Belgrade, Belgrade, Serbia; 4University Children’s Hospital, Pediatric Intensive Care Unit, Belgrade, Serbia; 5Emergency Medicine Center of Montenegro, Podgorica, Montenegro; 6Mother and Child Healthcare Institute of Serbia ‘Dr Vukan Cupic’, Department of Endocrinology, Belgrade, Serbia; 7School of Medicine, University of Montenegro, Podgorica, Montenegro; 8Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Department of Thyroid Gland Disease, Belgrade, Serbia
Objective: Progesterone (P4) is essential for successful embryo implantation and preventing miscarriage. The strong connection between thyroid autoimmunity (TAI) and infertility is highlighted in literature. Follicular fluid (FF) is important for the oocyte maturation. The aim of the study was to assess the influence of FF P4 in TAI positive women on assisted reproductive technology (ART) outcome.
Methods: The study included 52 women undergoing ART. Before the initiation of protocol for the controlled ovarian stimulation,thyrotropin (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroid peroxidase antibodies (TPOAbs) and thyroglobulin antibodies (TgAbs)levels were measured in serum, while TSH, fT4, TPOAbs, TgAbsand P4 levels were measured in FF on the day of oocyte retrieval. Depending of serum TPOAbs and/or TgAbslevels patients were divided into TAI positive group included 26 patients and 26 age and body mass index matched TAI negative controls.
Results: TAI positive women had less chance to achieve pregnancy (P = 0.004, OR = 0.036, 95% CI 0.004–0.347). However, no statistically significant difference of mean P4 FF level between women with 21 724.2 ± 12 157.3 ng/ml, and without TAI 20 676.6 ± 11 764.9 ng/ml was found (P = 0.754), and no statistically significant correlation was shown between FF P4 and serum and FF TPOAbs and TgAbs in groups. No statistically significant difference was found between FF P4 and the ART outcome, pregnancy per ET cycle in individual TAI positive and TAI negative groups, although, higher values of FF P4 were observed in subjects with pregnancy per ET cycle with borderline statistical significance (P = 0.060). It was shown that FF P4 is a significant predictor of ART outcome [log FF P4 P = 0.011, OR = 56.276 (95% Cl 2.542–1245.660)].
Conclusion: To the best of our knowledge, this is the first time to demonstrate the presence of P4 in FF of TAI positive women undergoing ART, and to estimate its impact on ART outcome. FF P4 was shown to be a significant predictor of ART outcome, for both women with and without TAI. Further studies are needed to estimate possible FF P4 threshold affecting ART outcome.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more