ECE2020 Audio ePoster Presentations Thyroid (144 abstracts)
Iodine deficiency and mortality in spanish adults. [email protected] study
Sergio Valdes 1 , Natalia Colomo 1 , Cristina Maldonado-Araque 1 , Eduardo García-Fuentes 2 , Alfonso Calle-Pascual 3 , Luis Castaño 4 , Elias Delgado 5 , Josep Franch-Nadal 6 , Federico Soriguer 7 & Gemma Rojo-Martinez 1
1Hospital Regional Universitario de Málaga, IBIMA, CIBERDEM, Endocrinology and Nutrition, Málaga, Spain; 2Hospital Universitario Virgen de la Victoria, IBIMA, CIBEROBN, UGC de Aparato Digestivo, Málaga, Spain; 3Hospital Universitario S. Carlos, CIBERDEM, Endocrinology and Nutrition, Madrid, Spain; 4Hospital Universitario Cruces, BioCruces Bizkaia, UPV/EHU, CIBERDEM, Barakaldo, Spain; 5Hospital Universitario Central de Asturias/ University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Endocrinology and Nutrition, Oviedo, Spain; 6EAP Raval Sud, Institut Català de la Salut, Red GEDAPS, Primary Care, Unitat de Suport a la Recerca (IDIAP – Fundació Jordi Gol), CIBERDEM, Barcelona, Spain; 7Academy of Science, Málaga, Spain
Objective: To study the association between the state of iodine nutrition, and the risk of total and cause mortality in a representative sample of the Spanish adult population.
Design: Longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the national study [email protected] (2008–2010). We used Cox regression to assess the association between IU at the start of the study (<50, 50–99, 100–199, 200–299 and ≥ 300 µg/l) and mortality during follow-up (INE- end of follow-up December 2016) in raw models and adjusted to possible confounding variables: age, sex, educational level, hypertension, DM, Obesity, CKD, smoking, hypercholesterolemia, thyroid dysfunction, diagnosis of cardiovascular disease, cancer diagnosis, Area of residence, physical activity, adherence to Mediterranean diet, dairy intake and iodized salt.
Results: A total of 254 deaths were recorded during an average follow-up of 7.3 years. The causes of death were cardiovascular 71 (28%); cancer, 85 (33.5%) and other causes 98 (38.5%). Compared to the reference category with adequate iodine nutrition (IU 100–300 µg/l) the Hazard Ratios of all-cause mortality in the category with IU ≥ 300 µg/l was 1.04 (CI 95% 0.54–1.98); however, in the categories with 50–99 IU and <50 µg/l, the Hazard Ratios were 1.29 (95% CI 0.97–1.70) and 1.71 (95% CI 1.18–2.48) respectively (P for trend 0.004). Multivariate adjustment did not significantly modify the results.
Conclusions: Our data indicate an excess mortality in individuals with severe iodine deficiency adjusted to other possible confounding factors.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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