ECE2020 Audio ePoster Presentations Thyroid (144 abstracts)
Retrospective incidence of NIFTP. A large multicentre Iberic study of over 3000 neoplasms
Miguel Paja 1,1 , M. Rosa Bella 2 , Carmela Iglesias 3 , Carles Zafón 4 , Jose M.l Cameselle 5 , Gemma Carnero 6 , Antónia Póvoa 7 , Aitziber Ugalde 8 , Emma Anda 9 , Pilar Fernández-Seara 10 , Nancy M. Sánchez-Gómez 11 , Hernán Quiceno 12 , Lluis García-Pascual 13 , Clarisa González 14 , Concepción Blanco 15 , Inés Gómez de la Riva 16 , Ismael Capel 17 , Isabel Mancha 18 , Helena Gallego 19 , Javier Maravall 20 , Esther Roselló 21 , Victoria Alcázar 22 , Montserrat Chao 23 , Antonia Lázaro 24 , Susana Lopez-Agulló 25 , Saioa Echeverría 26 , J.Joaquín Paricio 27 , Javier Sanz 28 , Pascual Messeguer 29 & Ángel Castaño 30
1Hospital Universitario de Basurto, Endocrinology, Bilbao, Spain; 2Hospital Universitario Parc Taulí, Pathology, Barcelona, Spain; 3Vall d’Hebron, Pathology, Barcelona, Spain; 4Vall d´Hebron, Endocrinology, Barcelona, Spain; 5Hospital Univ. Santiago de Compostela, Pathology, Santiago de Compostela, Spain; 6Hospital Univ. Santiago de Compostela, Endocrinology, Santiago de Compostela, Spain; 7C. H. Vila Nova de Gaia, Endocrine Surgery, Vila Nova de Gaia, Portugal; 8Hospital Universitario de Basurto, Pathology, Bilbao, Spain; 9Complejo Hospitalario de Navarra, Endocrinology, Pamplona, Spain; 100Complejo Hospitalario de Navarra, Pathology, Pamplona, Spain; 11Hospital U. Fundación Jimenez Díaz, Endocrinology, Madrid, Spain; 12Hospital U. Fundación Jimenez Díaz, Pathology, Madrid, Spain; 13Hospital U. Mútua Terrassa, Endocrinology, Terrassa, Spain; 14Hospital U. Mútua Terrassa, Pathology, Terrassa, Spain; 15Hospital Universitario de Alcalá, Endocrinology, Alcala de Henares, Spain; 16Hospital Universitario de Alcalá, Pathology, Alcala de Henares, Spain; 17Hospital Universitario Parc Taulí, Endocrinology, Sabadell, Spain; 18Hospital Universitario Virgen de la Victoria, Endocrinology, Málaga, Spain; 19Hospital Universitario Virgen de la Victoria, Pathology, Málaga, Spain; 20Hospital General Universitario de Castellón, Endocrinology, Castellón, Spain; 21Hospital General Universitario de Castellón, Pathology, Castellón; 22Hospital Severo Ochoa de Leganés, Endocrinology, Leganés; 23Hospital Severo Ochoa de Leganés, Pathology, Leganés; 24Hospital U. i Politècnic La Fe, Endocrinology, Valencia; 25Hospital U. i Politècnic La Fe, Pathology, Valencia; 26Clínica U. de Navarra, Endocrinology, Pamplona; 27Clínica U. de Navarra, Pathology, Pamplona; 28Hospital Lluis Alcanyís de Xàtiva, Endocrinology, Xàtiva; 29Hospital Lluis Alcanyís de Xàtiva, Pathology, Xàtiva; 300Hospital de Fuenlabrada, Pathology, Fuenlabrada
The newly created NIFTP category (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) has had a notorious impact in the management of thyroid neoplasms. Its incidence appears to be higher in western countries than Asiatic, but there are few studies including more than one institution.
Objectives: To evaluate retrospectively the incidence of NITFP in a multicentre study in two adjacent countries as well as to compare the results among institutions.
Methods: Sixteen institutions from Spain (15) and Portugal (1) took part in the study. Each of them made a retrospective review of its surgical cases of Follicular Variant of Papillary Thyroid Carcinoma (FVPTC) and Well-Differentiated Tumour of Uncertain Malignant Potential (WDT-UMP) from January 1st, 2005 to December 31th, 2015. The final pathology reports were reviewed and potential NIFTPs over 5 mm were retrieved for a pathological review.
Results: Among the 3185 cases with the diagnosis of papillary thyroid carcinoma (PTC) there were 900 (28.3%) of FVPTC added to 14 cases of WDT-UMP. After the review of the archived slides of the selected cases by the own pathologist in each centre, 175 were reclassified as NIFTP, 35 of them (20%) between 5 and 10 mm of size. They included seven of 14 WDT-UMP (50%) and 168 of 900 FVPTC (18.7%). The distribution by centre varied from 0% (no NIFTP among 16 FVPTC) in the centre with the lowest incidence, to 43.5% (10 NIFTP among 23 FVPTC) in the hospital with the highest incidence. The 3 institutions with more than 100 cases of FVPTC revised had an incidence from 15.9 to 25.4%. The most frequent cause of surgery was cytological or histological study with fine needle aspiration or core needle biopsy, including 58.3% of cases. Eight glands showed two foci of NIFTPs and two of them three foci. Mean size of the main focus of NIFTP was 21.8 mm (
Conclusion: In our geographic area, NIFTPs comprise 5.3% and 18.7% of cases previously classified as PTC and FVPTC respectively. We found that half of neoplasms named as WDT-UMP matched to NIFTP in its histological re-evaluation. The incidence of this diagnosis varies widely between hospitals separated by a few hundred kilometres. The cause of this difference remains elusive, and we propose that it could lie in the stringency of histological criteria for assigning a tumour as PTC when each pathologist evaluates nuclear changes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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