ECE2020 Audio ePoster Presentations Reproductive and Developmental Endocrinology (79 abstracts)
The diagnostic value of antimullerian hormone in polycystic ovary syndrome among Tunisian women: A case-control prospective study
Marwa Bennour 1 , Ines Kammoun 1 , Marouen Braham 2 , Hajer Kandara 1 , Manel Hamdoun 3 , Anis Fadhlaoui 3 , Olfa Bahri 3 , Fethi Zhioua 2 & Manel Jmal 1
1National Institute of Nutrition, Endocrinology and metabolic diseases, Tunis, Tunisia; 2Aziza othmana hospital, Department of Gynécologie, obstetric et reproduction medicine, Tunis, Tunisia; 3Aziza othmana hospital, Biochemistry laboratory, Tunis, Tunisia
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder. The presence of polycystic ovarian morphologyis usually confirmed by ovarian ultrasound. However, its definition is controversial. The objective of this study was to evaluate the interest of the antimullerian hormone (AMH) in the diagnosis of PCOS, aiming to establish a threshold that would be predictive of PCOS among Tunisian women.
Patients and Methods: Sixty-twoyoung women (31 with PCOS and 31 age and BMI matched healthy controls) were recruited in this case-control, prospective, cross-sectional study. All participants had physical examination, ovarian ultrasound and dosage of AMH and testosteronemia.
Results: All patients had clinical and/or biological hyperandrogenism. The mean rate of AMH was 3.6 times higher in patients (7.69 ng/ml) compared to controls (2.12 ng/ml; P < 10–3). The cut-off value for AMH which was best correlated with PCOS was 3.41 ng/ml (sensitivity = 96.8%; specificity = 90.3%; AUC = 0.977). A significant positive correlation between AMH and antral follicular number, and between AMH and testosteronemia was found. A significant negative correlation between AMH and age was also found. We noted no significant association between AMH and BMI. The most common PCOS phenotype was the A one combining the three diagnostic criteria for PCOS (52%). This phenotype had the highest rate of AMH.
Conclusions: Our results suggest that AMH may be a reliable biomarker in the diagnostic of PCOS. It may replace ovarian ultrasound if it is not available, inconclusive and/or in the absence of a qualified operator. The threshold of 3.41 ng/ml would be appropriate for Tunisian hyperandrogenic patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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