ECE2020 Audio ePoster Presentations Reproductive and Developmental Endocrinology (79 abstracts)
Early menopause is associated with increased risk of arterial hypertension: A systematic review and meta-analysis
Panagiotis Anagnostis 1,2 , Patroklos Theocharis 1,2 , Konstantinos Lallas 1 , Georgios Konstantis 1 , Konstantinos Mastrogiannis 1 , Julia Bosdou 1 , Irene Lambrinoudaki 3 , John Stevenson 4 & Dimitrios Goulis 1
1Aristotle University of Thessaloniki, 1st Department of Obstetrics and Gynecology, Medical School, Thessaloniki, Greece; 2Police Medical Centre of Thessaloniki, Department of Endocrinology; 32nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Medical School, Athens, Greece; 4National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom
Objective: Menopausal transition has been associated with an increased risk of cardiovascular disease (CVD), mainly attributed to atherogenic dyslipidaemia, central obesity and insulin resistance. Whether arterial hypertension (AH) also contributes to menopause-associated CVD is currently unknown. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the association between early menopause (EM) and AH risk.
Methods: A comprehensive search was conducted in PubMed, CENTRAL and Scopus databases, up to January 20th, 2020. Data were expressed as odds ratio (OR) with 95% confidence intervals (CI). The I2 index was employed for heterogeneity.
Results: Ten studies were included in the quantitative analysis (273.994 postmenopausal women, 76853 cases with AH). Women with EM (age at menopause <45 years) were at higher AH risk compared with those of normal age at menopause (>45 years) (OR 1.10, 95% CI 1.01–1.19, P = 0.03; I2 79%).
When women with POI were compared with those of normal menopausal age (five studies, 192.219 women), the association between POI and AH risk was not significant (OR 1.14, 95% CI 0.95–1.37, P = 0.17; I2 58%). Furthermore, when sensitivity analysis was restricted to studies (n = 8) in which participants were matched for age or BMI or smoking, the direction or the magnitude of the effect observed did not changed (OR 1.13; 95% CI, 1.00–1.29; P = 0.05). This was also the case after restricting analysis to studies (n = 2) matched for ever use of menopausal hormone therapy or oral contraceptives (OR 1.26; 95% CI 1.05–1.52; P = 0.01).
Conclusions: Women with EM have an increased risk for AH compared with those of normal age at menopause.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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