ECE2020 Audio ePoster Presentations Adrenal and Cardiovascular Endocrinology (121 abstracts)
Adrenal incidentalomas and renal cysts – the definitive sign of aging?
Ljiljana Marina 1,2 , Miomira Ivovic 1,2 , Milina Tancic-Gajic 1,2 , Zorana Arizanovic 1 , Aleksandra Kendereski 1,2 , Antoan Stefan Sojat 1 , Aleksandar Filipovic 3 , Dragan Vasin 3 , Andja Cirkovic 4 , Dragana Rakovic 1 , Milan Radovic 2,5 , Ana Bontic 5 , Kristina Nedic 2 , Tijana Petkovic 1 , Isidora Petkovic 2 , Sladjana Mihajlovic 2,6 , Marija Stevanovic 2 & Svetlana Vujovic 1,2
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Department for Obesity, Metabolic and Reproductive Disorders, Belgrade, Serbia; 2Faculty of Medicine, University of Belgrade, Serbia, Belgrade, Serbia; 3Centre for Radiology and Magnetic Resonance Imaging, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Serbia, Belgrade, Serbia; 4Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Serbia, Belgrade, Serbia; 5Clinic for Nephrology, Clinical Centre of Serbia, Belgrade, Serbia; 6University Hospital Centre Dr Dragisa Misovic, Belgrade, Serbia
Introduction: The prevalence of adrenal incidentalomas (AI) and renal cysts increase with age. Depending on the study population age and sex, on average, both are prevalent with about 8 to 10% in subjects older than 50 years of age.
Aim: We aimed to investigate the co-occurrence of AI and simple renal cysts.
Methods: Our study included 970 subjects, 494 with AI – all evaluated in single centre, and 476 control group (CG) patients (not harboring AI) enrolled from trauma patients admitted to the emergency room with performed CT scan of abdomen. Patients with polycystic kidney disease, end-stage kidney disease, hydronephrosis and known malignant diseases were not included in the study.
Results: There was no significant difference in age (AI: 60.79 ± 10.26 years, CG: 61.80 ± 9.59 years, P > 0.05) nor gender (male/female, AI: 163/330, CG: 181/295, P = 0.107) between AI and CG. Simple renal cysts were significantly more prevalent in patients with AI than in CG, 33.1% vs 19.5%, P < 0.001. In both groups patients with cysts were significantly older than those without them (AI: 62.45 ± 9.00 vs 56.99 ± 10.38 years, P < 0.001 and CG: 64.20 ± 9.26 vs 61.22 ± 9.59 years, P = 0.007, respectively). Gender distribution was the same between patients with and without cysts in both study groups. Among AI patients the presence of cysts was not dependent on the level of cortisol suppression in 1mg dexamethasone suppression test (cortisol: <50 nmol/l, P = 0.661 and <140 nmol/l, P = 0.248). The prevalence of renal cysts among unilateral and bilateral tumours was the same (P = 0.814) and it was not dependent on the size of the adrenal tumour.
Conclusion: Patients with AI are more likely to harbor a renal cyst(s) then patients without AI. Also, our study points to the significance of aging to occurrence of both AI and renal cysts.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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