ECE2020 Audio ePoster Presentations Adrenal and Cardiovascular Endocrinology (121 abstracts)
Subtyping of primary aldosteronism in patients with partially successful adrenal vein sampling
Karin Zibar Tomšić 1 , Vilim Molnar 2 , Tina Dusek 1,2 , Ivana Kraljevic 1 , Tanja Skoric Polovina 1 , Annemarie Balasko 1 , Mirsala Solak 1 , Hrvoje Popovac 1 , Nino Matas 3 & Darko Kastelan 1,2
1Department of Endocrinology, University Clinical Hospital Center Zagreb; 2School of Medicine, University of Zagreb; 3Department of Internal Medicine, General Hospital Dubrovnik
Introduction: Adrenal vein sampling (AVS) is a gold standard in the assessment of the cause of primary aldosteronism (PA). It is technically demanding procedure having the high rate of failure, even in expert centres. Our study aimed to investigatewhether the data on aldosterone and cortisol concentration from successfully cannulated adrenal vein could determine the subtype of PA in certain patients with partially successful AVS.
Materials and methods: The study included 36 AVS procedures performed in 35 patients (one patient undergone AVS twice). Unilateral aldosterone secretion was confirmed in 12 patients who were all surgically treated and achieved biochemical remission of the disease. In the remaining 23 patients, AVS results were consistent with bilateral adrenal hyperplasia. In all patients aldosterone/cortisol ratio between the peripheral and adrenal veins, as well as aldosterone/cortisol ratio in adrenal veins were analysed.
Results: Statistical analysis, using ROC curve, showed that peripheral/adrenal vein aldosterone/cortisol ratio > 2.3 (100 % sensitivity, 88% specificity) OR aldosterone/cortisol ratio in adrenal vein < 0.64 (92% sensitivity, 93% specificity) indicate unaffected adrenal gland.
Conclusions: Aldosterone/cortisol ratio in adrenal vein of < 0.64 and aldosterone/cortisol ratio between the peripheral and adrenal vein of > 2.3 are consistent with unaffected adrenal gland indicating that excess aldosterone secretion originates from the opposite side.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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