Endocrine Abstracts

Background: To predict severe acute pancreatitis (AP) at early stage is important to reduce morbidity and mortality. We aimed to investigate the association between the triglyceride and glucose index (TyG index) and the prognosis of acute pancreatitis.

Methods: The TyG index was calculated as the ln[fasting triglycerides (mg/dl) × fasting plasma glucose (mg/dl)]/2. Patients were then categorized into low TyG index group (<5) and high TyG index group (≥5). Multivariable logistic regression analysis was used to investigate the independent association between TyG index and the severity of AP.

Results: A total of 313 patients with AP were recruited in this study. The proportion of patients with severe AP and the percentage of intensive care unit admissions and mortality were higher in patients with high TyG index than in those with low TyG index. The hospital stay was longer in patients with high TyG index (7.9 vs 6.0 days, P = 0.019) and the area under the curve of TyG index for predicting severe AP was 0.731 (95% CI 0.64–0.82, P < 0.001). TyG index was the significant independent factor for severe AP (OR 2.59, 95% CI 1.27–5.30, P = 0.009) and intensive care unit (OR 7.34, 95% CI 2.89–18.65, P < 0.001). (Table 1)

Conclusion: Our findings suggest that the TyG index is an independent prognostic factor in patients with AP and may be suitable as a simple prognostic indicator for severe AP.