ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
Impact of interval walking training on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes mellitus
Jelizaveta Sokolovska 1 , Ksenija Krilatiha 2 , Karina Ostrovska 3 , Leonora Pahirko 4 , Gunita Varblane 1 , Austris Cirulnieks 2 , Aija Klavina 3 & Leo Selavo 2
1University of Latvia, Faculty of Medicine, Riga, Latvia; 2University of Latvia, Faculty of Computing, Riga, Latvia; 3Latvian Academy of Sport Education, Riga, Latvia; 4University of Latvia, Faculty of Physics, Mathematics and Optometry, Riga, Latvia
Background: Physical activity is the first-line treatment in type 2 diabetes. Interval walking training has demonstrated good tolerability and more pronounced positive effects on physical fitness and metabolism in type 2 diabetes, compared to continuous walking. However, the effects of interval walking on vascular health markers, such as albuminuria, has not been extensively studied. Type 2 diabetes is associated with derangements in leptin/adiponectin axis, which might predispose affected individuals to vascular inflammation. The aim of this randomized controlled study was to investigate the effects of interval walking training delivered through smart mobile devices upon albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes.
Methods: The study randomized patients with type 2 diabetes aged 35–75 into control (n = 26) and interval training (IT, n = 14) groups. Patients in IT group had to perform three 60-min interval walking sessions (3 min intervals of slow and fast walking with the intensity of 40% and 70% of the peak energy expenditure) per week delivered by smartphone application for four months. The adherence to training protocol was monitored remotely. Variables measured were albuminuria, leptin/adiponectin ratio, glycaemic control, lipid profile, anthropometric measures. Leptin and adiponectin concentration was measured in serum samples was measured by Luminex technology.
Results: In the IT group compared to control group, we observed a statistically significant decrease in albuminuria (P = 0.002, interaction effect) and leptin/adiponectin ratio (P = 0.01, interaction effect). As albuminuria and leptin/adiponectin ratio have been associated with progression of vascular complications of diabetes, our results indicate that interval walking training is effective for improvement of vascular health in diabetes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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