Endocrine Abstracts

Background: Recently, vitamin D3 deficiency is considered one of the factors associated with the development of non-alcoholic fatty liver disease (NAFLD). The aim was to evaluate steatosis indices and metabolic parameters in NAFLD depending on D3 status.

Materials and methods: According to the recommendations of the European Society of Endocrinology, all patients were divided into 3 groups: group 1 – with an optimal level of vitamin D3 (30 ng/ml); group 2 – D3 insufficiency (21–29 ng/ml) and group 3 – D3 deficiency (< 20 ng/ml).

Results: The study included 126 T2D patients with NAFLD diagnosed with US. The highest hepatic steatosis (HSI) and fatty liver (FLI) index values were diagnosed in D₃ deficiency as compared to optimal group (HSI – 43.34 ± 6.59 vs 39.67 ± 4.37; P = 0.032 and FLI – 79.21 ± 19.61 vs 64.96 ± 17.72; P = 0.007). Triglyceride and glucose index (TyG) also insignificantly growth parallel to D3 status worsened (P = 0.175). In multivariate logistic regression analysis according to the results obtained, regardless of the transaminases activity HSI (Nagelkerke R² = 0.215) and FLI (Nagelkerke R² = 0.163) were associated with vitamin D₃ deficiency. According to other logistic models, HSI and TyG indices (Nagelkerke R² = 0.358) as well as body mass index (BMI) and T2D duration (Nagelkerke R² = 0.328) were independent predictors associated with D3 deficiency in this cohort of patients.

Conclusions: hepatic steatosis indices (HSI, FLI and TyG) independently from anthropometric parameters and transaminase activity associated with D3 deficiency in NAFLD patients.