ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
HSEI ‘Bukovinian State Medical University’, Department of Clinical Immunology, Allergology and Endocrinology, Черновцы, Ukraine
During the last three decades the number of patients with diabetes mellitus (DM) type 2 have increased, which is associated with an increase in the prevalence of obesity among the world’s population. DM type 2 and obesity are closely linked with the production of leptin by adipose tissue. Diseases of the thyroid gland (TG) as well as type 2 DM are the most common endocrine pathologies. Many studies have found an increase of antithyroid antibodies titers against the background of DM type 2. According to the literature data, a chronic autoimmune thyroiditis (AIT) affects 10% of women and 20% of male population.
The aim of the study: To determine the characteristics of antithyroid autoimmunity in patients with type 2 diabetes mellitus, depending on the leptin level in blood serum and develop a method of the identified changes correction.
Materials and methods: Depending on the leptin level in blood serum patients were divided into groups as follows: Group I – level of leptin – less than 10 ng/ml (12 patients), group II – level of leptin within 10–25 ng/ml (19 patients), group III – level of leptin more than 25 ng/ml (15 patients).
Thyroid autoimmunity was diagnosed by antibodies to thyroid peroxidase (AT-TPO) and thyroglobulin (AT-TG) determination in the blood serum.
In order to evaluate the effectiveness of treatment, patients were randomly divided into two groups: 20 people with DM type 2 received standard treatment. The main group included 30 people who receivedsodium selenite, which is equivalent to 100 micrograms of selenium, by 1 tablet per day for 30 days against the background of basic therapy.
Results of the study: According to obtained data AT-TG level in group III was 2.1 times higher than in group I (P < 0.05). AT-TPO titers in groups II and III was 44.3% and 92.2%, respectively higher than in group I (P < 0.05).
A significant improvement of indicators that reflect the autoimmune processes against thyroid tissue have been found only in the group of persons who took sodium selenite with standard therapy: the level of AT-TG became 22.3% lower (P < 0.05) and AT-TPO – 30.6% than before sodium selenite treatment (P < 0.05)
Conclusions: 1. In patients with diabetes mellitus type 2 an antithyroid antibodies titers increase.
2. Significant decrease in antibodies to thyroglobulin and thyroid peroxidase titers in patients with type 2 diabetes mellitus against the background of sodium selenite intake have been observed.