Endocrine Abstracts

Psoriasis patients have an increased risk of cardiovascular disease, stroke, hypertension, and type 2 diabetes (T2D). External factors (infections, stress, trauma, endocrine diseases) can trigger psoriasis. Skin diseases in patients with T2D are increased, hyperglycemia leads to damage to vascular intima. Itching of the skin leads to disruption of the repair and regeneration.

Objective: To study the influence of T2D on the exacerbations of psoriasis.

Materials and methods: We studied hospitalized patients with T2D and psoriasis in dermatological clinic during 5 years (n = 47)-the main group. Comparison group 1-patients with psoriasis without T2D (n = 40), comparison group 2-patients with T2D without psoriasis (n = 37). Patients were excluded: with the psoriatic arthritis, GFR ≤ 45 ml/min/1.73 m².

Results: Patients of the main group (women-53.2%, men-46.8%, mean age 61.0 ± 7.7 years), comparison group 1 (women-55%, men-45%, mean age 60.5 ±7.5 years), comparison group 2 (women-54%, men-46%, mean age 62.0 ± 7.8 years) were same in clinical, anthropometric, anamnestic and laboratory data (AST, ALT, total cholesterol, creatinine, P > 0.05). Patients of the main group and comparison group 1 differed in serum glycemia (P = 0.005). Patients of the main group had an increase HLA1c level (11.8 (7.9–12.3)) compared with the comparison group 2 (6.8 (6.1–7.3), P = 0.006) in the exacerbation of psoriasis period.

The number of hospitalization in 5-year period was in 2.6 times higher in patients of the main group – 55 cases (1.17 exacerbations / person for a 5-years period), in the comparison group 1–18 cases (0.45 exacerbations/person for a 5-years period).

Conclusions: Psoriasis exacerbations in patients with psoriasis and type 2 diabetes were in 2.6 times often in 5-year period compared with psoriasis without type 2 diabetes. There is probably a correlation between psoriasis exacerbation and type 2 diabetes decompensation.