Endocrine Abstracts

Objective: Determination of changes in metabolic status and osteoprotegerin concentrations in obese children.

Methods: We examined 221 children in the University Hospital (Minsk) from 2017 to 2019 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of osteoprotegerin (OPG), insulin were determined. In the biochemical blood test, the parameters of uric acid, insulin were evaluated. All children were divided into 2 groups: group 1 children with morbid obesity – 159 patients (98 boys(B)/61 girls(G)) (BMI more than 99th percentile for sex and age) (BMI 32,95 ± 4,61 kg/m², age 14,16 ± 2,28 years); group 2 – 62 patients (B/G = 31/31) with alimentary obesity (BMI-95-99th percentile for sex and age) (BMI 27.86 ± 2.04 kg/m², age 14.77 ± 2.05 years). The control group consisted of 84 patients (B/G = 45/39) with normal body weight (BMI 19.86 ± 2.24 kg/m², age 14.32 ± 2.11 years).

Results: In the subgroups of boys with obesity, there were significant differences in the concentration of uric acid in comparison with the control (alimentary obesity 426.55 ± 62.25 mmol/l vs 242.58 ± 49.90 mmol/l (P = 0.01)), morbid obesity 324.10 ± 59.33 mmol/l vs 242.58 ± 49.90 mmol/l (P = 0.01)). Girls with obesity have a significant increase in uric acid level in comparison with the control group (alimentary obesity 328.10 ± 51.43 mmol/l vs 213.0 ± 39.64 mmol/l (P = 0.0001), morbid obesity 409.04 ± 84.23 mmol/l vs 213.0 ± 39.64 mmol/l (P = 0.0001)). In boys with obesity higher concentrations of OPG were detected relative to the control group (alimentary obesity 259.98 ± 108.07 ng/ml vs 225.12 ± 55.88 ng/ml (P = 0.09), morbid 322,22 ± 82,14 ng/ml vs 225.12 ± 55.88 ng/ml (P = 0.001)). In girls with obesity higher concentrations of OPG were detected relative to the control group (alimentary obesity 326.84 ± 104.02 ng/ml vs 254,39 ± 78,29 ng/ml (P = 0.046), morbid 347.33 ± 93,50 ng/ml vs 254.39 ± 78.29 ng/ml (P = 0.03)).

In boys with obesity higher concentrations of insulin were detected relative to the control group (alimentary obesity 18.9 ± 12.7 µU/ml vs 9.1 ± 4.2 µU/ml (P = 0.0001), morbid 28.71 ± 7.36 µU/ml vs 9.1 ± 4.2 µU/ml (P = 0.001)). In girls with obesity, the concentration of insulin relative to the control group was (alimentary obesity 20.28 ± 6.25 µU/ml vs 14.10 ± 6.80 µU/ml (P = 0.001)) morbid obesity 23.32 ± 9.65 µE/ml vs 14.10 ± 6.80 µU/ml (P = 0.001)).

Conclusion: Children with obesity have an increase in insulin and OPG rates.