Endocrine Abstracts

Introduction: Diabetic nephropathy is a clinical syndrome characterized by overt proteinuria and decreased renal function in the course of diabetes mellitus. The earliest symptom is the presence of albuminuria, but a decrease in glomerular filtration rate(GFR) has been observed in patients without albuminuria. In our study, it was aimed to investigate the presence and prevalence of nonalbuminuric diabetic kidney disease observed in patients with type 2 diabetes, and to determine the characteristics and prevalence of patient groups with this feature.

Material and Methods: Normoalbuminuric (n = 138), and albuminuric (n = 40) patients records with T2DM over 40 years of age, followed by 2014–2018 in our clinic, with GFR < 60 ml/min/1.73 m² were examined retrospectively. Various demographic and diabetes-related clinical and laboratory features and risk factors of patients in the study group were recorded. These variables in the group of patients with normoalbuminuric were compared with albuminuric patients. During the comparison, nonparametric methods were used because the patient distribution wasn’t normal. We want to share the data of the first 138 patients as a preliminary evaluation, since the study was not completed.

Results: In the study, 93 female and 45 male patients were found to be normoalbuminuric, 11 female and nine male patients were microalbuminuric, 12 female and eight male patients were macroalbuminuric. In the comparison between the groups, it was observed that normoalbuminuric patients were older than albuminuric patients, shorter diabetes duration, lower LDL and triglyceride levels, and HbA1C mean and arterial blood pressures were higher in albuminuric patients. Diabetes duration (P =0.047), HbA1C overall average (P = 0.048), retinopathy (P = 0.017) and macrovascular complications (P = 0.004) compared to Mann-Whitney-U test were significantly different between the groups (Table 1). Microalbuminuric and macroalbuminuric patients were compared due to the difference between the albuminuric and non-albuminuric groups and no significant difference was found in the parameters (P > 0.05).

Conclusion: These results emphasize the role of different variables in the development of diabetic nephropathy. Progress of renal dysfunction and albuminuria can be delayed if effective blood pressure control is achieved and blood lipids and HbA1C levels are kept within the treatment targets in normoalbuminuric patients.