ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
Physical activity is associated with lower arterial stiffness after the menopause: The effect of BMI
Eleni Armeni 1 , Stavroula Paschou 1 , Iliana Karagkouni 1 , Areti Augoulea 1 , George Georgiopoulos 2 , Dimitrios Rizos 3 , George Kaparos 3 , Konstantinos Panoulis 1 , Michael Apostolakis 1 , Nikolaos Tsoltos 1 , Kimon Stamatelopoulos 2 & Irene Lambrinoudaki 1
1National and Kapodistrian University of Athens, Aretaieio Hospital, 2nd Department of Obstetrics and Gynecology, Athens, Greece; 2National and Kapodistrian University of Athens, Alexandra Hospital, Department of Therapeutics and Vascular pathophysiology, Athens, Greece; 3National and Kapodistrian University of Athens, Aretaieio Hospital, Hormonal and Biochemical Laboratory, Athen
Introduction: Metabolic syndrome and cardiovascular disease (CVD) are well-known long-term implications of the menopausal transition. Lifestyle practices like exercise could potentially act protective with regards to future cardiovascular risk at midlife. We aimed to assess the impact of physical activity on the development of subclinical CVD in postmenopausal women, adjusting for the effect of underlying obesity.
Methods: This cross-sectional study from a University Menopause Clinic evaluated a total of 623 apparently healthy postmenopausal women. Anthropometric parameters were evaluated, and women were classified into normal weight [body mass index (BMI) ≤25 kg/m2 n = 194] and overweight-obese (BMI >25 kg/m2, n = 431). Fasting blood samples were obtained to assess biochemical and hormonal profile. Sonographical assessment was performed immediately thereafter including functional [pulse wave velocity, (PWV)] and structural markers [intima media thickness (IMT) and atherosclerotic plaques presence] of subclinical vascular disease. Main outcome measures consisted of the extent of subclinical CVD according to severity of physical activity and the potential confounding effect of obesity.
Results: In the total sample, mean values of PWV differed according to the intensity of physical activity (sedentary vs walking vs moderate vs vigorous: 9.07 ± 1.22 m/s vs 9.12 ± 1.72 m/s vs 8.47 ± 1.31 m/s vs 7.94 ± 0.40 m/s, ANOVA P-value for linear trend 0.003). Physical activity of moderate intensity is associated with lower levels of PWV (b-coefficient = −0.126, P-value = 0.001), adjusting for age, menopausal age, BMI, lipids, insulin resistance, smoking, blood pressure. This was not the case for walking or activity of severe intensity. Overweight-obese vs normal weight women had higher levels of common carotid artery (CCA) IMT (13.8 ± 1.0 mm vs 13.3 ± 1.5 mm, P-value = 0.005), greater PWV (9.1 ± 1.5 m/s vs 8.4 ± 1.5 m/s, P-value < 0.001) and higher frequency of plaques in CCA (54.9% vs 30.6%, P-value <0.001). In the subgroup analysis, the association between physical activity and PWV remained significant only for women with normal weight but not for overweight-obese participants.
Conclusion: Physical activity seems to be related with a protective effect on the extent of subclinical CVD in postmenopausal women. Exercise of moderate intensity is linked with lower levels of PWV after the menopause, an effect mainly pronounced in normal weight women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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