ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
1Centro Hospitalar Universitário São João, Porto, Portugal, Department of Endocrinology, Diabetes and Metabolism, Portugal; 2Universidade do Porto, Faculdade de Medicina, Portugal; 3Institute of Public Health of the University of Porto (ISPUP), Portugal; 4Instituto De Investigação e Inovação em Saúde, Universidade do Porto (I3S), Portugal
Introduction: Magnesium (Mg) is an essential mineral for human health. Chronic Mg2+ deficiency and low Mg2+ dietary intake have been associated with increased risk of T2DM. Despite the increased risk of T2DM associated with Mg2+ deficiency; T2DM is often accompanied by hypomagnesemia, especially in patients with poorly controlled glycemic profiles.
Bariatric surgery remains the most effective long-term therapy for the management of patients with severe obesity. After surgery, micronutrient deficiencies are one of the most common and compelling problems.
Objective: To analyse the effect of Mg supplementation and serum levels in T2DM metabolic parameters and remission after bariatric surgery.
Methods: We performed a cross-sectional study of obese patients who underwent bariatric surgery. Data was assessed preoperatively and one-year after surgery. T2DM was defined as fasting plasma glucose (FPG) ≥126 mg/dl, glycated haemoglobin (HbA1c) ≥6.5%, 2-h plasma glucose after a 75-g oral glucose tolerance test ≥200 mg/dl or the use of anti-diabetic medication (ADM). Complete T2DM remission was defined as HbA1C < 6.0% and no ADM use and partial T2DM remission was defined as HbA1C < 6.5% and no ADM use.
Results: Of a total of 2241 patients submitted to bariatric surgery, we included 644 patients with T2DM. At baseline, 39% of the patients (n = 251) had Mg deficiency and only 4% of them were on Mg supplementation. Patients with Mg deficiency had poorer metabolic control (HbA1c, FPG, insulin, C peptide, HOMA-IR and number of ADM) compared with patients without Mg deficiency with statystical significance for HbA1c (HbA1c = 6.55 ± 1.34 vs HbA1c = 7.17 ± 1.55, P < 0.0001), FPG (FPG = 112.45 ± 28.28 vs FPG = 122 ± 42.58, P < 0.006), and number of ADM (ADM = 1.063 ± 0.89 vs ADM = 1.39 ± 1.07, P < 0.0001). At the first year, 16.1% of patients had complete T2DM remission. It was more common among patients without Mg deficiency (P < 0.001). Similar to baseline, patients withoug Mg deficiency had better metabolic control with statystical significance.
Conclusion: Mg supplementation and higher serum Mg levels in patients with T2DMwere associated with better metabolic control and higher rates of complete and partial remission at the first year post-surgery.