ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
Metabolic and cardiovascular consequences of Ramadan fasting in type 2 diabetic patients
Fatma Boukhayatia 1 , Ibtissem Oueslati 1 , Meriem Cheikh 1 , Bassem Hammami 2 , Asma Kardi 1 , Meriem Yazidi 1 , Moncef Feki 2 , Neila Ben Romdhane 3 & Melika Chihaoui 1
1La Rabta hospital, Department of endocrinology, Tunis, Tunisia; 2La Rabta hospital, Laboratory of biochemistry, Tunis, Tunisia; 3La Rabta hospital, Laboratory of hematology, Tunis, Tunisia
Introduction: Ramadan fasting stands for abstaining from eating, drinking, smoking and oral medication use from predawn to sunset during one month. The duration of the fast from 10 to 19 hours, lifestyle changes and sleep disturbances can affect the glycemic control in diabetic patients with a high risk of hypoglycemia and hyperglycemia. However, fasting has been shown to improve insulin sensitivity and reduce oxidative stress, inflammation and the risk of atherosclerosis.
The objective of our study was to assess the impact of fasting on metabolic and cardiovascular profile in type 2 diabetic patients.
Methods: We conducted a prospective case-crossover observational study including 47 type 2 diabetic patients treated with metformin and / or sulphonylurea, with an HbA1c < 10% and who intended to fast the month of Ramadan 2019, in the absence of a major contraindications. Clinical and biological parameters were evaluated before (T0) and after the month of Ramadan (T1). Cardiovascular risk was estimated using the Framingham score.
Results: Study population included 26 women and 21 men with a mean age of 54.5 ± 10.3 years. The mean level of HbA1c before the month of Ramadan was 6.9 ± 0.9%. The number of days of fasting was 29.25 ± 2.31 days. The prevalence of hypoglycemia symptoms was 15%. No severe complications were recorded. During Ramadan fasting, dietary intake decreased by 19%. At T1, a weight loss was observed in 70% of cases with a significant reduction in weight (P = 0.004), body mass index (P = 0.005) and waist circumference (P = 0.02). However, changes in blood pressure, fasting blood glucose, fructosamine level, total-cholesterol, triglycerides, HDLc, LDLc, uric acid and HOMA-IR index were not significant. There were a decrease in high-sensitivity CRP level (P = 0.05) and in fibrinogen level (P = 0.005). A decrease in Framingham score occurred in 35% of participants with a decline of 5.9 ± 3.6%.
Conclusion: Ramadan fasting reduced the cardiovascular risk in type 2 diabetics, essentially through an improvement in the inflammatory and anthropometric status. Moreover, favorable changes in lipid profile and blood pressure were not significant in our study.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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