Endocrine Abstracts

Objectives: To analyze the indicators of carbohydrate metabolism depending on the characteristics of the manifestation of hypoglycemic reactions.

Materials and methods: The study daily glucose dynamics was carried out with Medtronik MINIMED Continious Glucose Monitoring System (CGMS), USA.

The standard glycose profile (4–5 per day) was measured in capillary blood with the Precision PCχTM glucose meter, MediSense. To analyze the continuous glycemic curve, the risk indices (RIn) of hypoglycemia and hyperglycemia were calculated over the study period.

We have examined 162 patients with diabetes mellitus type 1.

There was group 1 with the presence of hypoglycemic reactions (n = 99), and group 2 with the absence of hypoglycemic reactions (n = 63).

The groups are comparable in terms of mean age (28.59 ± 7.10 years), duration of DM type 1 (10.46 ± 7.28 years), and BMI (24.12 ± 3.62 kg/m²).

Results: in the total number of examined, the median RIn of hyperglycemia was 13.15 [9.00; 20.00], RIn of hypoglycemia was 5.25 [2.00; 9.60], HbA1C level was (9.00% [7.70; 10.60]).

When taking into account the presence of hypoglycemic reactions in the group 1, RIn of hyperglycemia was 11.80 [9.00; 18.30], RIn of hypoglycemia was 8.15 [4.50; 12.90], in group 2, RIn of hyperglycemia was 18 30 [10.20; 24.80], RIn of hypoglycemia was 1.20 [0.25; 3.25].

Assessing RIn of hypo- and hyperglycemia in groups taking into account the severity, in group 1, the high RIn of hypo- and hyperglycemia (76%) prevailed over the low one (RIn of hypoglycemia 10% and RIn of hyperglycemia (8%) P < 0.001, in group 2 low RIn of hypoglycemia (69%) and high RIn of hyperglycemia (78%) accounted for the majority (P < 0.001).

Conclusions: In the examined patients with DM type 1, the median RIn of hyperglycemia and RIn of hypoglycemia corresponds to a high risk of developing hyper- and hypoglycemic conditions and indicates decompensation of DM 1.

Decompensation of DM type 1 in patients with hypoglycemic episodes is caused by posthypoglycemic hyperglycemia.