Endocrine Abstracts

Thrombocytes play important role in pathogenesis of diabetic vascular complications.

Aim: To study peculiarities of thrombocyting haemostasisin children with diabetes mellitus type 1 (T1DM).

Patients and Methods: 120 children (66 boys, 54 girls) 3–17 y.o. with T1DM were examined. The duration of the disease was: less than 1 year in 29 patients (HbAc1 7.5 ± 0.4%) – group 1, from 1 to 5 years in 41 patients (HbAc1 8.7 ± 1.4%) – group 2, more then 5 years in 50 children (HbAc1 11.4 ± 2.2%) – group 3. Control group: 60 healthy children 3–17 y.o. The indexes of trombocyte aggregation (degree, speed and time of aggregation) measured by laser method with different inductors (ADP, adrenalin, kollagen) and intravascular aggregation were evaluated.

Results: Level of adrenalin-stimulating aggregation, speed of kollagen-stimulating aggregation and intravascular aggregation of thrombocytes were increased in group 1 in comparance of control group (P < 0,05). Levels of ADP- and kollagen-stimulating aggregation (P < 0,05) and intravascular aggregation (P < 0,001) were also increased in group 2. Decrease of aggregation time was revealed in this group (P < 0,05). Increase of all indexes of functional activity of thrombocytes (P < 0,05) and increase of intravascular aggregation (P < 0,001) were found in patients of group 3 in comparance of control group.

Conclusions: The changes of thrombocyting haemostasisin children with T1DM were reveald. Functional activity of thrombocytes in this children appeared to increase in correlation with duration of the disease and it may demand treatment.