ECE2020 Audio ePoster Presentations Bone and Calcium (121 abstracts)
Parathyroid carcinoma: An italian multicenter retrospective analysis
Laura Gianotti 1 , Elena Castellano 1 , Corrado Lauro 2 , Alessandro Piovesan 3 , Massimo Procopio 3 , Marco Barale 3 , Nicola Palestini 4 , Francesco Quaglino 5 , Luca Manfrino 5 , Valentina Bullara 6 , Marco Volante 7 & Giorgio Borretta 1
1Santa Croce & Carle Hospital, Department of Endocrinology, Diabetes and Metabolism, Cuneo, Italy; 2Santa Croce & Carle Hospital, Department of Surgery, Cuneo, Italy; 3AOU Città della Salute della Scienza di Torino, Department of Endocrinology, Turin, Italy; 4Candiolo Cancer Institute I.R.C.C.S, Thyroid and Parathyroid Surgery, Candiolo, Italy; 5“Maria Vittoria” Hospital ASL Città di Torino, Department of General Surgery, Turin, Italy; 6Ospedale Maggiore di Novara, Novara, Italy; 7San Luigi Gonzaga University Hospital, Sanatorio San Luigi, Italy
Parathyroid carcinoma (PC) is a rare neoplasia responsible for about 1% of primary hyperparathyroidism (PHPT). Differently from patients with its benign counterpart, the phenotype of these patients is characterized by severe PHPT and hypercalcemia. The aim of this study was to describe a series of PC casesrecorded in the regional cancer network of Piedmont and Valle d’Aosta, Italy (Rete Oncologica del Piemonte e della Valle d’Aosta) from 2007 to 2017, including 25 patients (11 males and 14 females, mean age 59 yrs) from four hospitals (AO S. Croce e Carle in Cuneo, AOU Città della Salute e della Scienza and ASL Città di Torino in Turin and AOU Ospedale Maggiore della Carità in Novara). Disease incidence, gender, age at time of diagnosis, presence of renal and bone symptoms, serum calcium and PTH levels, surgical technique performed and percentage of recurrence were analysed. A PC incidence of 0.05 cases per 100.000 inhabitants was found in this region. PC occurred equally in males and females and affected patients mostly in their fifties. Concomitant hypercalcemia and increased PTH were present in all patients. Typical PHPT symptoms were reported in 92% of PC cases. In this series, en-bloc resection showed a 13 times lower risk of relapse compared to all the other surgical techniques. A not-radical surgical resection is associated with a higher recurrence rate. In conclusion, this series confirms that PC is equally gender distributed, with average age at diagnosis earlier than benign PHPT. A meticulous pre surgical evaluation of PHPT patients who show evocative features of PC is mandatory in order to adopt an appropriate approach and treatment of this disease.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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