ECE2020 Audio ePoster Presentations Bone and Calcium (121 abstracts)
Quality of life, depressin and anxiety in patients with hypoparathyroidism
İnan Anaforoglu 1 , Seda Sancak 2 , Emin Murat Akbas 3 , Gonca Oruk 4 , Masum Canat 5 , Kadriye Aydın 6 , Ziynet Alphan Uc 7 , Suheyla Gorar 8 , Gulhan Cavlak 9 , Guzin Eren 10 , Merve Yılmaz 11 , Betul Ekiz Bilir 12 , Humeyra Bozoglan 13 , Gulhan Akbaba 14 , Mazhar Muslum Tuna 15 , Seckin Akcay 15 , Dilek Tuzun 16 , Gulay Simsek Bagir 17 , Filiz Eksi Haydardedeoglu 17 & Goknur Yorulmaz 18
1Bahcesehir University Faculty of Medicine, Istanbul, Turkey; 2Fatih Sultan Mehmet Education and Research Hospital, Endocrinology and Metabolism, İstanbul, Turkey; 3Erzincan Binali Yıldırım University Faculty of Medicine, Endocrinology and Metabolism, Erzincan, Turkey; 4Izmir Katip Celebi University Ataturk Education and Research Hospital, Endocrinology and Metabolism, İzmir, Turkey; 5Saglık Bilimleri University Sisli Etfal Education and Research Hospital, Endocrinology and Metabolism, İstanbul, Turkey; 6Saglık Bilimleri University Kartal Education and Research Hospital, Endocrinology and Metabolism, İstanbul, Turkey; 7Usak University Faculty of Medicine, Endocrinology and Metabolism, Usak, Turkey; 8Saglık Bilimleri University AntalyaEducation and Research Hospital, Endocrinology and Metabolism, Antalya, Turkey; 9Cumhuriyet University Faculty of Medicine, Endocrinology and Metabolism, Sivas, Turkey; 10Pamukkale University Faculty of Medicine, Endocrinology and Metabolism, Denizli, Turkey; 11Gazi Devlet Hastanesi, Endocrinology and Metabolism, Samsun, Turkey; 12Tekirdag Devlet Hastanesi, Endocrinology and Metabolism, Tekirdag, Turkey; 13Giresun Prof Dr Ilhan Ozdemir Education and Research Hospital, Endocrinology and Metabolism, Giresun, Turkey; 14Mugla Sıtkı Kocman University Faculty of Medicine, Endocrinology and Metabolism, Mugla, Turkey; 15Saglık Bilimleri University Umraniye Education and Research Hospital, Endocrinology and Metabolism, Istanbul, Turkey; 16Kahramanmaras Sutcu Imam University Faculty of Medicine, Endocrinology and Metabolism, Kahramanmaras, Turkey; 17Baskent University Faculty of Medicine, Endocrinology and Metabolism, Adana, Turkey; 18Eskisehir Osmangazi University Faculty of Medicine, Endocrinology and Metabolism, Eskisehir, Turkey
Patients with hypoparathyroidism may have sypmptoms consistent with physical, emotional and cognitive dysfunctions which may cause impaired quality of life (QOL). We included 266 patients (20–79 years; 231 women/35 men) who were being treated for hypoparathyroidism. They were taking conventional therapies for hypoparathyroidism; calcium, active vitamin D and magnesium when needed. We applied Beck Depression Scale, Anxiety Scale and SF-36 QOL scale to the patients. The etiologic factors were thyroid surgery (n = 198), autoimmune (n = 41) and surgery for thyroid cancer (n = 27). The etiologic cause of hypoprathyroidism did not show any correlation with questionnare scores. As thyroid cancer might be an additional stress factor we evaluated it as an independent factor but it had no impact on parameters. Duration of hypoparathyroidism had no effect on parameters (P = 0.662). Serum calcium, and magnesium had a negative correlation with anxiety and depression scores (anxiety; P = 0/r = −0.336, P = 0.001/r = −0.210, depression; P = 0/r = −0.258, P = 0.001/r = −0.210, respectively). SF-36 parameters did not have any correlation with serum calcium and magnesium. Serum phosphorus and vitamin D levels did not have any correlation with depression, anxiety or SF-36 parameters. Frequency of admission to the emergency unit with hypocalcemic crisis did have a positive correlation with anxiety and depression scores (P = 0.001/r = 0.202; P = 0.004/ r = 0.171, respectively) and a negative correlation with general health status (P = 0.001/r = −207). Compliance to the therapy (skipping calcium, magnesium or active vitamin D preparations) affected patients’ scores. Anxiety and depression scores were higher among noncompliant patients (anxiety; 25.6 ± 14.9 vs 18.6 ± 12.7, P = 0, depression; 18.4 ± 12.7 vs 13.7 ± 11.6, P = 0.001, respectively). As expected SF-36 scores were lower among noncompliant patients (vitality; 39.1 ± 21.6 vs 49.3 ± 22.1, P = 0, mental health; 54.1 ± 18.7 vs 59.3 ± 20.2, P = 0.027, social function; 59.1 ± 25.6 vs 67.5 ± 25.4, P = 0.004, bodily pain; 49.8 ± 28 vs 56.9 ± 27.7, P = 0.031, general health; 43.2 ± 20.9 vs 49.4 ± 19.6, P = 0.012). Conventional therapy does not meet the needs of patients with hypoparathyroidism. It has been shown thatnewly discovered parathyroid hormone therapy may improve QOL of patients. Further studies are needed.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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