ECE2020 Audio ePoster Presentations Hot topics (including COVID-19) (110 abstracts)
Low FT3 serum values are associated with markers of disease severity, evaluated during the acute phase of COVID-19
Salvatore Sciacchitano 1 , Simonetta Giovagnoli 2 , Michela D’Ascanio 3 , Chiara De Dominicis 4 , Andrea Laghi 5 , Paolo Anibaldi 6 , Claudia De Vitis 1 , Andrea Petrucca 7 , Rachele Amodeo 8 , Maurizio Simmaco 9 , Christian Napoli 4 , Rita Mancini 1 & Alberto Ricci 1
1Sapienza University of Rome, Clinical and Molecular Medicine, Roma, Italy; 2Sapienza University of Rome, Division of Pneumology, Roma, Italy; 3Sapienza University of Rome, Department of Clinical and Molecular Medicine, Roma, Italy; 4Sapienza University of Rome, Medical and Surgical Sciences and of Translational Medicine, Roma, Italy; 5Sapienza University of Rome, Roma, Italy; 6Sant’Andrea Hospital, Health Managment Director, Rome, Italy; 7Sapienza University of Rome, Neuroscience, Mental Health and Sense Organs, Sapienza University, Roma, Italy; 8Sapienza University of Rome, Flow Cytometry Unit, Clinical Laboratory, Roma, Italy; 9Sapienza University of Rome, Neuroscience, Mental Health and Sense Organs, Roma, Italy
Low T3 syndrome is a frequent finding in patients with critical illness, particularly in those admitted to intensive care units. It is generally considered an adaptive state of thyroid hormone (TH) economy, but many evidences indicate that it may represent a negative prognostic factor too. The prevalence and clinical relevance of the Low T3 syndrome in coronavirus infections has not been evaluated yet. We have measured thyroid hormone levels and analyzed anamnestic, epidemiological, clinical, biochemical and radiologic data of 62 patients affected by COVID-19 in search of possible correlation between all these parameters and the serum FT3 values. Patients were subdivided into two groups according to their serum FT3 levels, measured during the acute phase of the disease. Group A consists of 38 patients showing low levels of FT3 (<1.7 pg/ml) and Group B consists of 24 patients with normal levels of FT3 (>1.7 pg/ml and < 3.71 pg/ml). We have measured several serum markers, radiologic and clinical scores of the severity of the disease and we have searched for a possible correlation between FT3 serum values and all these markers and scores. We observe a positive correlation with many disease severity markers and scores examined. The Absolute Neutrophil Count, the related NLR and dNLR ratios are higher in Group A, compared to Group B. Reduced FT3 serum values correlates with reduced total count of CD3 + lymphocytes and with reduction of both helper-inducer and suppressor-cytotoxic T cells. Low FT3 values correlate also with increased levels of inflammation, tissue damage and coagulation serum markers. Finally, low FT3 serum levels correlated with Sequential Organ Failure Assessment (SOFA) score, Lung Inflammation Prognostic Index (LIPI) and radiological Total Severity Score (TSS). Our study demonstrates that low levels of FT3, during the acute phase of COVID-19, are associated with biomarkers of tissue damage, inflammation, coagulation and with scores, indexes of clinical and radiological severity of the disease. Low FT3 serum levels can be considered as a novel biomarker of the severity of the disease.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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