Endocrine Abstracts

Background: Although obesity and has been associated with COVID-19 mortality, the absolute and relative risks for Type 2 diabetes (DM2) is unknown. The aim of this study was to analyse metabolic characteristics of patients infected by COVID-19 hospitalised and evaluate whether DM2 have an impact in this group of patients.

Methods: We retrospectively analysed data of COVID-19 patients hospitalized to a large academic hospital system in Zaragoza between March 6st and April 02th, 2020. Data included demographics, comorbidities and biochemical parameters. The time-dependent probability of death was evaluated using the Kaplan-Meier method. Univariable and multivariable logistic regression models were performed. P value < 0.05 was considered significant.

Results: The study included 149 patients (87 men) with a mean age of 67.91 years (s.d. 17.03). Hypertension (50.3 %), dyslipidemia (23.5%) and diabetes (20.8%) were the most prevalent comorbidities. By multivariable regression analysis, both Charlson comorbidity index (CCI) (OR 1.627, CI 95% [1.183–2.321] P = 0.01)and a neutrophil to lymphocytes ratio (NLR) > 10 (OR 4.249, CI 95% [1.419–12.724] P = 0.010)were associated with a higher risk of COVID-19 mortality. In univariate proportional analysis DM2 (OR 4, CI 95% [1.708–9.367] P = 0.01), was associated with mortality, but it was not significant in the multivariable analysis.

Conclusion: Our study demonstrates that hospitalized patients with DM2 are more likely to die from COVID-19. CCI and NLR were both good predictors of mortality in this population.