Endocrine Abstracts

Background and aim: Chronic Kidney Disease and Diabetes Mellitus can influenceCoronary Artery Disease (CAD) independently. The aim of this study was to evaluate the association of Glomerular Filtration Rate (GFR) and Coronary Artery Disease in type 2 diabetic patients. (T2DM)

Methods: This cross sectional study evaluated 362 T2DM patients with clinical presentation of CAD whose documents were registered in angiography center during 18 months. GFR was measured by MDRD method and divided into 5 subgroups: GFR < 15, 15 ≤ GFR < 30, 30 ≤ GFR<60, 60 ≤ GFR < 90 and GFR ≥ 90. Then the association of 5 subgroups of GFR with coronary angioplasty in T2DM patients was evaluated. The association between age, sex, hypertension, and dyslipidemia with 5 subgroups of GFR was also studied.

Results: Among 3624 T2DM patients, 36% had GFR < 60 (ml/min/1.73 m²).The highest frequency percentage of coronary angioplasty (53%) was observed in the GFR stage 3 (30–60) ml/min/1.73 m². A significant inverse association was observed between the GFR of T2DM patients and the frequency percentage of coronary angioplasty. (P-value < 0.001).There was also a significant association between GFR<60 and history of hypertension and dyslipidemia. (P-value < 0.001). Using regression analysis, it was shown that GFR can be an independent factor to predict coronary artery disease. (P value = 0.02, β = 1.003).

Conclusion: A reduced GFR in patients with diabetes increases CAD, independently of other risk factors.