ECE2020 Audio ePoster Presentations Adrenal and Cardiovascular Endocrinology (121 abstracts)
How innocent are nonfunctioning adrenal incidentalomas?
Akrivi Savelli 1 , Fani Athanassouli 1 , Fotini Petychaki 1 , Nikos Asonitis 1 , Ilias Giovanopoulos 1 , Michalis Samarkos 1 , Olga Benopoulou 2 , Irene Kourbeti 2 , Mina Psichogiou 1 , Marina Mantzourani 1 , Evangelos Cholongitas 1 , Helen Gogas 1 , Eva Kassi 1 & Anna Angelousi 1
1National and Kapodistrian University of Athens, Athens, Greece. 2Laiko Hospital, Athens, Greece.
Context: Adrenal incidentalomas (AI) can be found in 3–10% of the general population. The vast majority of them (70%) represents nonfunctioning adrenal incidentalomas (NFAI). Although several comorbidities have been studied in patients with autonomous cortisol secretion (ACS) there are limited data for those with NFAI.
Aim: To study metabolic disorders frequency in patients with AI and especially NFAI.
Design: Retrospective study.
Methods: Seventy AI and 50 controls were recruited from the 1st Department of Internal Medicine in “Laiko” Hospital, Athens (Greece). NFAI were selected based on current guidelines. The control group was selected based on normal adrenal imaging exams (Computerized Tomography (CT)). Patients and controls were matched forage, sexand menopausestatus. Patients receiving any medication that could affectcortisol levels were excluded.
Results: Sixty patients (86%) presented NFAI and 10 patents ACS AI (14%). The 27% of the patients were diagnosed with bilateral AI and were more commonly classified as ACS compared to NFA (P = 0.005). Adrenocorticotropic hormone (ACTH), urinary free cortisol levels (UFC) and cortisol levels after (1 mg-ODST) differed significantly between NFAI and ACS AI (P < 0.05) as it was expected,in contrast with morning cortisol levels (P = 0.48). AI size was higher in ACS compared to NFAI (P = 0.009). The patients bearing NFAI and ACS AI had higher Body Mass Index (BMI) (P = 0.048 and 0.02 respectively), higher fasting blood glucose (P = 0.009 and 0.03) and Hb1Ac compared to controls (P = 0.04 and P = 0.05, respectively). The presence of NFAI was correlated with higher incidence of diabetes mellitus and hypertensioncompared to controls (33% vs 10%,and 37% vs11%, respectively). Serum cortisol levels in 1-mg ODST in NFAI group although normal (<1.8mg/dl) were positively correlated with Hb1Ac levels (r = 0.66, P = 0.05). No other metabolic disorders (i.e. dyslipidemia, osteoporosis) were correlated with the presence of AI.
Conclusions: The frequency of ACS among patients with AI is not negligible. Patients with NFAI exhibitmore commonly glucose metabolism disorders and obesity as compared to controls. Further investigations with larger sample are necessary to elucidate the aetiopathogenesis of metabolic disorders in this population.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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