ECE2020 Audio ePoster Presentations Hot topics (including COVID-19) (110 abstracts)
The association between systolic blood pressure reduction during clonidine suppression testing and the decrease in plasma catecholamines and metanephrines
Tiran Golani 1,2 , Boris Fishman 1 , Yehonatan Sharabi 1 , Yael Olswang-Kutz 3 , Avshalom Leibowitz 1 , Ehud Grossman 1 & Gadi Shlomai 1,2,4
1The Chaim Sheba Medical Center, Internal Medicine D and Hypertension unit, Tel Hashomer, Israel; 2Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv-Yafo, Israel; 3The Chaim Sheba Medical Center, The Metabolic Lab, Tel Hashomer, Israel; 4The Chaim Sheba Medical Center, Institute of Endocrinology, Diabetes and Metabolism, Tel Hashomer, Israel
Background: Borderline isolatednorepinephrine (NE) and normetanephrine (NMT) elevation is common among patients with suspected pheochromocytoma and paraganglioma (PPGL). The clonidine suppression test (CST) may help establish the etiology in these cases. Prolonged laboratory processing and/or paucity of reliable biochemical assaysmay limit the utility of CST. The aim of this study was to evaluate whether blood pressure (BP) reduction during CST is associated with alterations in plasma NMT/NE, thereby potentially providing an immediate indicationof CST results.
Methods: A cross sectional study, including all consecutive patients with suspected PPGL who underwent CST from 1st January 2014 to 31st December 2019. Linear regression models were conducted to evaluate the association between BP reduction and decrease in plasma NMT/NE.
Results: The final analysis included 36 patients (17 males). The decrease in Systolic BP (SBP) 90 minutes post clonidine was associated with a decrease inplasma NMT (R = 0.668, P = 0.025) and NE (R = 0.562, P = 0.005). A 40% decrease in NMT and NE correlated with a 9.74% and 7.16% decrease in SBP, respectively. Subgroup analyses demonstratedthat the association between SBP reductionand the decrease in plasma NMT (R = 0.764, P = 0.046) and NE (R = 0.714, P = 0.003) strengthens among patients with hypertension and among those with diabetes mellitus (R = 0.974, P = 0.026 for NMT).
Conclusions: SBP reduction during CST is associated with plasma NMT and NE decrease. Therefore, the decrease in SBP90 minutes post clonidine mayserve as an immediate complementary clinical tool for PPGLdiagnosis.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more