Searchable abstracts of presentations at key conferences in endocrinology
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22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

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Europe's leading endocrinology congress showcasing the very best in the study and treatment of endocrine disorders.

Symposia

New horizons in phaeochromocytoma and paraganglioma

ea0070s1.2 | New horizons in phaeochromocytoma and paraganglioma | ECE2020

Combination targeted therapies for malignant tumours – towards precision medicine

Nölting Svenja

For metastatic phaeochromocytomas (PCCs) and paragangliomas (PGLs), there are currently no highly effective therapies available. We therefore investigated multiple novel molecular-targeted drug combinations in murine PCC cell lines and, most importantly, in human PCC/PGL 2D and 3D primary cultures (n = 18). Additionally, we analysed signalling pathway alterations as well as somatic mutations in the patients’ tumours in order to correlate these data with drug responsi...