ea0070s1.2 | New horizons in phaeochromocytoma and paraganglioma | ECE2020
Nölting Svenja
For metastatic phaeochromocytomas (PCCs) and paragangliomas (PGLs), there are currently no highly effective therapies available. We therefore investigated multiple novel molecular-targeted drug combinations in murine PCC cell lines and, most importantly, in human PCC/PGL 2D and 3D primary cultures (n = 18). Additionally, we analysed signalling pathway alterations as well as somatic mutations in the patients’ tumours in order to correlate these data with drug responsi...