Endocrine Abstracts

Recent studies have reported that tissue micro-environment including tumor infiltrating lymphocytes (TILs) as well as neo-angiogenesis played pivotal roles in biological and clinical behavior of various human malignancies. In adrenal neoplasms, TILs are far more frequently detected in cortical than medullary tumors. In adrenocortical adenomas, we have recently demonstrated that enhanced angiogenic chemokines, especially CXCL12, in cortisol producing adenoma (CPA), induced TILs...

MicroRNAs, the endogenous mediators of RNA interference have been shown to be helpful as markers of malignancy and prognosis in various neoplasms. The use of microRNAs as biomarkers has been greatly expanded with findings showing their secretion into body fluids (liquid biopsy). MicroRNAs are released both passively due to necrosis and inflammation, and actively in extracellular membrane vesicles (exosomes, microvesicles) or in macromolecular complexes. Circulating microRNA ca...

Adrenocortical Carcinoma (Adrenal Cancer or ACC) is a rare malignancy. It requires multidisciplinary care to manage the multiple endocrine and oncologic manifestations of the disease. We will use the recently published international ACC Guidelines to illustrate essential components of the standard of care work-up, diagnosis, and management of ACC. As an understanding of genetics is becoming increasingly mainstream in cancer biology and care including adrenocortical carcinoma (...