Endocrine Abstracts

Background: Most thyroid specific genes are transcriptionally regulated by TSH-TSHR signalling and T4-driven negative feedback of TSH secretion at the pituitary. However, local autoregulation of transcription has been described from IGF-IGFR, follicular thyroglobulin, or iodine. We aimed to investigate the TSH dependency of thyroid transcriptional regulation in the Dehal1 knockout, devoid of iodide-recycling capacity from iodotyrosines.Methods: ...

Background and Aim: The incidence of papillary thyroid microcarcinoma (mPTC) has dramatically increased in the last decades. The majority of these tumors remain small and clinically silent, only small number progress. Clinical practice guidelines currently suggest avoiding the cytological examination of subcentimeter nodules and reducing surgeries for mPTC. Several risk factors have been identified as strongly associated with a high-risk phenotype for mPTCs (e.g. gross nodal m...

Purpose: Methimazole (MMI) is a widely used antithyroid agent for first-line treatment of hyperthyroidism. A warning has been recently issued by the European Medicine Agency (EMA) regarding a potential increased risk of acute pancreatitis (AP) in MMI users, based on evidences from published case reports and post-marketing surveillance. The aim of this study was to investigate the association between MMI treatment and the diagnosis of AP in drug users.Mat...

New combinatorial drug strategies are urgently needed to improve radioiodine (RAI) uptake and efficiently ablate thyroid cancer cells, thereby reducing the risk of recurrent disease. Drug repurposing offers the promise of identifying already approved compounds capable of inducing sodium iodide symporter (NIS) function to enhance iodide uptake. However, a lack of thyroid cell-based assays amenable to high-throughput screening has limited progress. We utilised the mutated yellow...

Objective: Immune checkpoint inhibitors (ICI) are used for treatment of non-small cell lung cancer (NSCLC) and are associated with immune-related adverse events (irAEs), especially thyroid dysfunction. Few studies found an association between thyroid dysfunction and response to Nivolumab in the NSCLC The objective of this retrospective cohort study was to investigate the association between the occurrence of thyroid dysfunction in patients treated with Nivolumab for a NSCLC an...

Context: Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) is an autoimmune endocrinopathy with severe and unpredictable course. Previous studies have reported increased mortality in patients with APECED. However, the impact of APECED on mortality has not been previously determined.Objective: To systematically study overall and cause-specific mortality in patients with APECED. Design and Setting: A follow-up study of Fin...

Background: The prescription of triiodothyronine (T3) for hypothyroidism is increasing worldwide, however, long-term effects of its use are largely unknown. Previous studies have suggested possible association between T3 use and breast cancer. The aim of the study was to examine the effects of T3 use on cancer incidence and mortality.Material: Our sample included the full adult population of individuals living in Sweden with at least three purchases of t...