Endocrine Abstracts

The lifelong exposure to mixtures of endocrine disrupting chemicals raises serious concerns about their deleterious effects on human health. Polychlorinated biphenyls (PCBs) had widespread use in numerous industrial applications, and were massively produced for several decades. After the discovery of the adverse effects of PCBs in the 1970s, brominated flame retardants (BFRs) were established as the major chemical flame retardant. Both chemicals persist in the environment and ...

Introduction: The metabolic risk associated with air pollution could vary according to the specific pollution levels of each area, as well as factors related to lifestyle (diet, activity physical, socioeconomic status, tobacco), other exposures, comorbidities etc.. and has been insufficiently evaluated in our country.Objective: To study the association between long term exposure to air pollution (measured as PM concentrations) and the incidence of hypert...

Limited research has been conducted on adrenal gland as target of endocrine disrupting chemicals (EDCs). Moreover, studies on steroidogenesis as the target of EDCs has also attracted lesser attention compared to other metabolic pathways. We studied the effects of two extensively used phthalate esters viz., di-ethyl hexyl phthalate (DEHP) and di-butyl phthalate (DBP) on the adrenal gland in Wistar rats and checked its susceptibility against the exposure of these extensively use...

Introduction: Hashimoto’s thyroiditis (HT) is a complex disease which is caused by genetic as well as environmental factors. While the genetic predisposition to HT has been extensively investigated, the influence of most environmental factors still needs to be evaluated. Based on our previous study, we did not find any correlation between HT and the fact of cigarette smoking or the number of pack-years. We did, however, find a significant correlation between the age of s...

There have been raising concerns in the effects of endocrine disrupting chemicals like triclosan (TCS) on the embryo development. Triclosan (TCS) is commonly present in household and personal wash products We hypothesize that exposure to TCS during early stage of development could alter brain development affecting behavior. To test this hypothesis, primary cortical neurons were exposure to TCS with/without estrogen antiestrogen ICI 182780 from day in vitro 1 to 4. We also addr...

Introduction: Santé publique France develops a national epidemiological monitoring program to study health indicators related to endocrine disruptor exposure. Based on the weight of evidence, cryptorchidism was selected for this purpose. In this study, we aimed to analyze temporal, spatial and spatio-temporal trends of cryptorchidism during the period 2002–2014 in France, and explore and/or generate environmental hypotheses.Methods: We built a...