ECE2020 ePoster Presentations Thyroid (122 abstracts)
Can platelet and neutrophil to lymphocyte ratios be used as predictive markers for malignancy in thyroidectomy patients?
Oana Stefana Enache 1 , Sorina Martin 1,2 , Theodor Mustata 2 , Oana Ion 3 , Andreea Chifulescu 4 , Ovidiu Parfeni 1 , Anca Sirbu 1,2 , Carmen Barbu 1,2 , Cosmin Giulea 5,6 , Adrian Miron 5,6 , Florin Andrei 7 & Simona Fica 1,2
1Elias Hospital, Endocrinology, Bucharest, Romania; 2Carol Davila University of Medicine and Pharmacy, Endocrinology, Bucharest, Romania; 3Fundeni Clinical Institute, Nephrology, Bucharest, Romania; 4Fundeni Clinical Institute, Gastroenterology, Bucharest, Romania; 5Carol Davila University of Medicine and Pharmacy, Surgery, Bucharest, Romania; 6Elias Hospital, Surgery, Bucharest, Romania; 7Elias Hospital, Pathology, Bucharest, Romania
Objectives: In recent studies, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are being investigated as prognostic and diagnostic markers for many malignancies, including thyroid cancer. The aim of our study was to investigate if a relationship exists between NLR and PLR and thyroid cancer.
Materials and methods: We retrospectively analysed the files of 953 patients who underwent thyroidectomy in our surgery department between January 2012 – December 2017. In the study were included 205 patients with differentiated thyroid carcinoma (DTC) and 108 age- and gender-matched patients with benign thyroid pathology. Anthropometric, biologic and imagistic data, indication of thyroid surgery, surgical procedures and pathology results were recorded.
Results: Age at diagnosis was 52.06 ± 13.22 years for DTC patients (83.4% women) and 52.07 ± 12.902 years for patients with benign thyroid pathology (83.3% women). Before surgery, NLR and PLR were similar in both groups (2.40 ± 1.03 in the DTC patients vs 2.41 ± 1.38 in benign pathology patients, P = 0.958, respectively 137.6 ± 47.29 vs 130.69 ± 44.22, P = 0.209). Younger DTC patients had significantly higher PLR than those with benign pathology (under 45 years: 145.79 ± 49.67 vs 45 years and older: 116.50 ± 34.26, P = 0.006; under 55 years: 142 ± 47.97 vs 55 years and older: 125.30 ± 42.26, P = 0.030). In the DTC group, men had significantly higher NLR compared to women (2.75 ± 1.10 vs 2.33 ± 1, P = 0.029). Post surgery, NLR was 2.65 ± 1.37 vs 2.17 ± 0.89 (P = 0.063), while PLR was significantly higher in the DTC group than in the benign pathology group (147.96 ± 54.47 vs 125.05 ± 34.95, P = 0.025).
Conclusions: In our study, men with DTC had higher NLR than women, while PLR was higher in the cancer group, but statistical significance was obtained only for younger patients (< 45 and < 55 years) before surgery and after surgery for all DTC patients compared to benign pathology group. This could be explained by the changes in immunity that appear with aging, but the relationship between NLR and PLR and thyroid cancer needs to be further investigated.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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