Endocrine Abstracts

The aim of the study was to assess the role of the estradiol and progesterone relationship during the late luteal phase and the occurrence of fibrocystic breast disease (FBD). The concentration of E2/P was measured in the group of women with FBD as study group and healty control group. All women had regular ovulation cycles. Blood samples for E2, P and prolactin determination were obtained in the morning at 8 am on days 21 and 24 of menstrual cycle. Significant mastalgia and mastodynia history in women with FBD was obtained with yes or no questionnaire. FBD diagnosis was confirmed with ultrasound. In the control group, a reduced E2/P ratio was noticed from day 21 to day 24 of the cycle, which was not recorded in the group of women with FBD (study group). Even the slightest disturbance of the E2/P ratio may contribute to the occurrence of benign breast disease with clinical manifestations of mastalgia and mastodynia.